3-Hydroxy-2-naphthamide

Basic Information

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CAS Number

3665-51-8

Molecular Formula

C11H9NO2

Molecular Weight

187.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

211-216 ºC

Boiling Point

321.94°C (rough estimate)

Refractive Index

1.4900 (estimate)

SMILES

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C1=CC=C2C=C(C(=CC2=C1)C(=O)N)O

InChI

InChI=1S/C11H9NO2/c12-11(14)9-5-7-3-1-2-4-8(7)6-10(9)13/h1-6,13H,(H2,12,14)

InChIKey

NFTNTGFZYSCPSK-UHFFFAOYSA-N

LogP

1.6442999999999999

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

229

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS003613091
UNII-I7M9NQ16EI
3-HYDROXY-2-NAPHTHALENECARBAMIDE
Z68590127
3-HYDROXY-2-NAPHTHOAMIDE
NSC 37060
3-hydroxynaphthalene-2-carboxamide;3-Hydroxy-2-naphthamide
2-NAPHTHAMIDE, 3-HYDROXY-
AS-12392
NS00030072
2-Naphthalenecarboxamide, 3-hydroxy-
Oprea1_641266
3-Hydroxy-2-naphthamide
3665-51-8
NSC37060
WLN: L66J CVZ DQ
2-Hydroxy-3-naphthamide
2-Hydroxy-3-naphthoamide
4-10-00-01188 (Beilstein Handbook Reference)
DTXSID8063123
2-hydroxy-3-naphthoic acid amide
NFTNTGFZYSCPSK-UHFFFAOYSA-N
I7M9NQ16EI
NSC-37060
MFCD00082972
3-Hydroxynaphthalene-2-carboxamide
2-Hydroxy-3-naphthalenecarboxamide
CS-0207345
BRN 1104926
FT-0747941
SCHEMBL550901

MDL Number

MFCD00082972

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 3-Hydroxy-2-naphthamide (CAS: 3665-51-8)?

3-Hydroxy-2-naphthamide (CAS: 3665-51-8) is a crystalline compound with a molecular weight of approximately 186.18 g/mol. It has a pKa around 9.8, indicating basic properties. The compound is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It is not highly reactive but can undergo substitution reactions under certain conditions. It has a melting point of about 220-222°C.

How is 3-Hydroxy-2-naphthamide (CAS: 3665-51-8) typically synthesized?

3-Hydroxy-2-naphthamide can be synthesized via a multi-step process involving the condensation of 2-naphthylamine with acetic anhydride followed by hydrolysis. The reaction is carried out under mild conditions with good yield. Common catalysts used include phosphoric acid, and the process is typically performed in organic solvents to enhance reactivity.

What industries use 3-Hydroxy-2-naphthamide (CAS: 3665-51-8)?

3-Hydroxy-2-naphthamide (CAS: 3665-51-8) is used in various industries, particularly in the pharmaceutical sector for the synthesis of drugs, and in the polymer industry for the production of special plastics. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 3-Hydroxy-2-naphthamide (CAS: 3665-51-8)?

When handling 3-Hydroxy-2-naphthamide (CAS: 3665-51-8), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, immediate cleanup should be performed using appropriate absorbent materials, and the area should be rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information.