Cinacalcet hydrochloride

Basic Information

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CAS Number

364782-34-3

Molecular Formula

C22H23ClF3N

Molecular Weight

393.88 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

175-177°C

SMILES

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CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

InChI

InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

InChIKey

QANQWUQOEJZMLL-PKLMIRHRSA-N

LogP

6.563800000000005

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

422

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

BCP9000286
1-Naphthalenemethanamine, alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-, (alphaR)-, hydrochloride
alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride
CINACALCET HYDROCHLORIDE [WHO-DD]
Cinacalcet hydrochloride (JAN/USAN)
Tox21_112654_1
D03505
Mimpara (TN)
NPS-1493
364782-34-3
(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine HCl
NCGC00181002-01
UNII-1K860WSG25
Cinacalcet hydrochloride
(R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1- -(1-napthyl)ethylamine Hydrochloride
AMG073 HCl
CHEMBL1200776
SMR002530058
CS-0288
BCPP000409
Z1741977003
N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
AMG-073 HCl (Cinacalcet hydrochloride)
CHEBI:48391
DTXSID3046792
CAS-364782-34-3
J-520045
N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride
N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
GS-4171
CINACALCET HYDROCHLORIDE [JAN]

MDL Number

MFCD08067750

Customs Code

2921499090

FAQ

What is Cinacalcet hydrochloride (CAS: 364782-34-3)?

Cinacalcet hydrochloride (CAS: 364782-34-3) is a calcimimetic agent used to lower calcium and phosphate levels in the blood. Its chemical formula is C19H25ClN2O4S, and it is a white to off-white powder with high water solubility. It functions by enhancing the sensitivity of the calcium-sensing receptor in parathyroid glands, making it effective for managing hyperparathyroidism.

What are the main uses of Cinacalcet hydrochloride (CAS: 364782-34-3)?

Cinacalcet hydrochloride (CAS: 364782-34-3) is primarily used in pharmaceuticals to treat secondary hyperparathyroidism in patients with chronic kidney disease. It is also employed in research for studying calcium metabolism and as a therapeutic option for hypercalcemia. Its applications are centered around regulating calcium and phosphate homeostasis.

Is Cinacalcet hydrochloride (CAS: 364782-34-3) safe?

Cinacalcet hydrochloride (CAS: 364782-34-3) is generally safe when used as directed, but it may cause side effects like hypocalcemia or gastrointestinal discomfort. Proper handling, including gloves and ventilation, is recommended to ensure safety. Adhere to regulatory guidelines for its use in medical and research settings.

How should Cinacalcet hydrochloride (CAS: 364782-34-3) be stored?

Cinacalcet hydrochloride (CAS: 364782-34-3) should be stored in a cool, dry place (15-25°C), protected from moisture and light. Keep in a sealed, airtight container to maintain stability. Avoid exposure to high humidity and ensure storage conditions comply with pharmaceutical standards for potency and safety.