Halofantrine hydrochloride

Basic Information

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CAS Number

36167-63-2

Molecular Formula

C26H31Cl3F3NO

Molecular Weight

536.89 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

93-96°; mp 203-204°

Boiling Point

596.2°Cat760mmHg

Density

1.244

Flash Point

314.4°C

Solubility

DMSO: >10mg/mL

SMILES

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CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl

InChI

InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H

InChIKey

WANGFTDWOFGECH-UHFFFAOYSA-N

LogP

9.066099999999999

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

584

Synonyms & References

English

1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl
1,3-Dichloro-alpha-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol;(+/-)-Halofantrine Hydrochloride
HALOFANTRINE HYDROCHLORIDE (MART.)
CCG-221031
3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol hydrochloride
MLS002154111
3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride
UNII-2B7ENL644K
Halofantrine hydrochloride (USAN)
Halofantrino [Spanish]
Halofantrine hydrochloride, (-)-
Halfan (TN)
(+-)-Halofantrine hydrochloride
1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride
HALOFANTRINE HYDROCHLORIDE [ORANGE BOOK]
WR-171669
W-106636
HALOFANTRINE HYDROCHLORIDE [MART.]
9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride, (-)-
1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride
66051-64-7
Halfan
1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl
Halofantrine hydrochloride, European Pharmacopoeia (EP) Reference Standard
dl-WR 171669
SCHEMBL466895
9-PHENANTHRENEMETHANOL, 1,3-DICHLORO-alpha-(2-(DIBUTYLAMINO)ETHYL)-6-(TRIFLUOROMETHYL)-, HYDROCHLORIDE (1:1)
(-)-Halofantrine hydrochloride
SKF-102886;WR-171669
9-PHENANTHRENEMETHANOL, 1,3-DICHLORO-.ALPHA.-(2-(DIBUTYLAMINO)ETHYL)-6-(TRIFLUOROMETHYL)-, HYDROCHLORIDE, (-)-
CHEMBL1200901

MDL Number

MFCD00879136

FAQ

What is Halofantrine hydrochloride (CAS: 36167-63-2)?

Halofantrine hydrochloride (CAS: 36167-63-2) is a medicinal compound primarily used as an antimalarial drug. It is a hydrochloride salt of halofantrine, a synthetic derivative of quinine, and is used to treat Plasmodium falciparum malaria.

What are the main uses of Halofantrine hydrochloride (CAS: 36167-63-2)?

Halofantrine hydrochloride (CAS: 36167-63-2) is mainly used in the treatment of Plasmodium falciparum malaria. It is also used in combination with other antimalarials to enhance efficacy and reduce the risk of resistance.

Is Halofantrine hydrochloride (CAS: 36167-63-2) safe?

Halofantrine hydrochloride (CAS: 36167-63-2) can be considered safe when used under medical supervision. However, it is important to follow dosing instructions and take preventive measures to avoid serious cardiac side effects, such as prolonged QT interval. Patients should avoid exposure to strong sunlight and monitor their heart rate and rhythm.

How should Halofantrine hydrochloride (CAS: 36167-63-2) be stored?

Halofantrine hydrochloride (CAS: 36167-63-2) should be stored in a cool, dry place, away from direct sunlight and moisture. It should be kept in a tightly closed container to protect from light and air. The storage temperature should not exceed 25°C (77°F) to maintain its efficacy and stability.