L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate

Basic Information

View in Editor

CAS Number

357166-29-1

Molecular Formula

C20H33N5Na2O13

Molecular Weight

597.48 g/mol

EINECS

639-569-0

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

white to beige

Melting Point

No data available

Boiling Point

No data available

Flash Point

No data available

Solubility

H2O: soluble30mg/mL, clear

Vapor Pressure

No data available

SMILES

View in Editor

[O-]C(=O)CC[C@@H](C(=O)[O-])NC(=O)c1ccc(cc1)CCc1c[nH]c2c1c(=O)nc([nH]2)N.[Na+].[Na+].O.O.O.O.O.O.O

InChI

1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1

InChIKey

AEZRDYKQLPDYEH-YTCXBBKHNA-N

Complexity

737

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.

Synonyms & References

English

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate
Pemetrexed disodium hepthydrate
PeMetrexed disodiuM 7-hydrate
L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, disodiuM salt, heptahydrate
Pemetrexed for system suitability
Pemetrexed (sodium salt hydrate)
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hepthydrate
7-dihydro-4-oxo-3H-pyrrolo[2
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate
Pemetrexed
Pemetrexed Disodium
Pemetrexed Disodium heptahydrate
PEMETREXED, DISODIUM SALT, HEPTAHYDRATE
HSDB 7316
LY 231,514
N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid sodium salt hydrate
N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid sodium salt hydrate
UNII-04Q9AIZ7NO
Alimta
9T47E4OM16
Alimta (TN)
disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;heptahydrate
Pemetrexed sodium hydrate (JAN)
QJVSMHJWAOSBMD-MYXYZBIASA-L
Pemetrexed Disodium Salt Heptahydrate
API0024628
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,
CID 135564751
Pemetrexed disodium heptahydrate
PemetrexedDisodiumHeptahydrate

MDL Number

MFCD09263275

EC Number

639-569-0

Customs Code

29335990

FAQ

What regulatory guidelines apply to L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1)?

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) is subject to various regulatory guidelines including GHS for hazardous classification, REACH for chemical registration, and FDA/EPA for safety and environmental standards. Detailed regulations may vary based on specific applications and jurisdictions.

Are there alternatives to L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) in synthesis?

In synthesis, alternatives to L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) may include similar compounds like 2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl derivatives or other pyrimidine-based analogs. Isomers and alternative reagents can also be explored for specific chemical reactions.

What is the market or research trend for L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1)?

The market for L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) is driven by its applications in pharmaceuticals and research. Recent trends include increased interest in its potential therapeutic effects, particularly in oncology. Research is also focusing on its use in developing new drug delivery systems and addressing market demand for innovative chemical entities.

How should waste containing L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) be handled?

Waste containing L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (CAS: 357166-29-1) should be managed by collecting it in appropriate containers and following local hazardous waste disposal regulations. Professional waste disposal services are recommended for safe incineration or other environmentally friendly disposal methods. Proper handling should also include precautionary measures to prevent environmental contamination and ensure safety of personnel.