(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (1:1) | CAS No. 357-08-4

(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (1:1)

Basic Information

CAS Number

357-08-4

Molecular Formula

C19H22ClNO4

Molecular Weight

363.84 g/mol

AD

Basic Physical Properties

Melting Point

200-2050C

Water Solubility

Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml) and dimethyl sulfoxide (73 mg/ml). Insoluble in ether

Solubility

ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.

C=CCN1CC[C@]23c4c5ccc(c4O[C@H]2C(=O)CC[C@]3([C@H]1C5)O)O.Cl

InChI

InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

InChIKey

RGPDIGOSVORSAK-STHHAXOLSA-N

LogP

1.7232000000000007

Topological Polar Surface Area

70.0 Ų

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

594

Safety Information

View Safety Information

Sensitiveness

对光和湿度敏感

Synonyms & References

English

  • naloxone hydrochloride
  • NALOXONE HCL
  • (5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE
  • 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride
  • 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride
  • 17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride
  • en1530
  • l-n-allyl-14-hydroxynordihydromorphinonehydrochloride
  • Naloxone (hydrochloride)
  • Naloxone Hydrochlori
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one,hydrochloride
  • Narcan
  • Narcanti
  • NIH 7890
  • Nalonee
  • F850569PQR
  • Evzio
  • MLS000069540
  • EN 15304
  • Naloxonehydrochloride
  • C19H21NO4.HCl
  • SMR000058766
  • naloxon
  • Naloxone Hydrochloride
  • (4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
  • hydrochloride (1:1)

FAQ

What is (5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (CAS: 357-08-4)?

(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (CAS: 357-08-4) is a semi-synthetic opioid analgesic. It contains a morphinan nucleus with specific functional groups, providing analgesic and antitussive properties.

What are the main uses of (5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (CAS: 357-08-4)?

(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride is primarily used in pharmaceuticals as a potent analgesic and antitussive agent. It has applications in managing moderate to severe pain and as an expectorant in respiratory conditions.

Is (5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (CAS: 357-08-4) safe?

(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride is generally considered safe when used as directed. However, it can cause side effects such as respiratory depression and dependence. Proper storage and use under medical supervision are essential for safety.

How should (5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (CAS: 357-08-4) be stored?

(5alpha)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride should be stored at controlled room temperature, between 15-30°C (59-86°F), in a tightly sealed container to protect it from moisture and light. Avoid storing it in direct sunlight or high humidity environments to maintain its efficacy and safety.

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