Bendamustine HCl

Basic Information

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CAS Number

3543-75-7

Molecular Formula

C16H22Cl3N3O2

Molecular Weight

394.73 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

152-156°C

Solubility

H2O: >30mg/mL

SMILES

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CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

InChI

InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H

InChIKey

ZHSKUOZOLHMKEA-UHFFFAOYSA-N

LogP

3.6864000000000026

Topological Polar Surface Area

58.36000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

380

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H351 Suspected of causing cancer
Carcinogenicity

H360 May damage fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 (monohydrate) in mice, rats (mg/kg): 400-500, 200-300 orally; 80, 40 i.v. (Horn)

Synonyms & References

English

Treanda (TN)
Cytostosan
Ribomustin
2-Benzimidazolinebutryric acid, hydrochloride
Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionicacid
BENDAMUSTINE HYDROCHLORIDE [ORANGE BOOK]
Cytostasan
SMR004234484
SB17462
Hydrochloride, Bendamustine
Q27272066
VIVIMUSTA
3543-75-7
MFCD16879055
Treakisym
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzoimidazol-2-yl)butanoic acid monohydrochloride
5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl
1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride
AS-15856
1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride
IMET 3393
Bendamustine hydrochloride [USAN:JAN]
DTXCID00111403
ZIMET 33/93
2-Benzimidazolebutyric acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride
WLN: T56 BN DNJ B1 C3VQ GN2G2G &GH
SDX-105 (Cytostasane) HCl
Bendamustine hydrochloride
Symbenda
Tox21_500623
UNII-981Y8SX18M

MDL Number

MFCD01658758

Customs Code

29339900

FAQ

What is Bendamustine HCl (CAS: 3543-75-7)?

Bendamustine HCl is a chemotherapeutic agent with the chemical formula C11H17N5O4S. It is a white to off-white crystalline powder that is soluble in water and has a molecular weight of approximately 303.34 g/mol. This compound is known for its alkylating properties and is used in the treatment of various cancers.

What are the main uses of Bendamustine HCl (CAS: 3543-75-7)?

Bendamustine HCl is primarily used in oncology as a chemotherapy drug for treating lymphomas, chronic lymphocytic leukemia, and other hematological malignancies. It is also utilized in research for studying DNA damage mechanisms and in pharmaceutical development for creating targeted cancer therapies.

Is Bendamustine HCl (CAS: 3543-75-7) safe?

Bendamustine HCl is considered safe when used under medical supervision, but it can cause side effects such as bone marrow suppression and gastrointestinal issues. Proper handling and adherence to safety guidelines are essential to minimize risks. It is classified as a Schedule II controlled substance in some regions due to its potential for abuse and toxicity.

How should Bendamustine HCl (CAS: 3543-75-7) be stored?

Bendamustine HCl should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature between 15°C to 25°C. Avoid exposure to moisture and ensure proper labeling to maintain stability and safety.