Ambrisentan Impurity 3

Basic Information

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CAS Number

35144-22-0

Molecular Formula

C7H10N2O2S

Molecular Weight

186.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

80.0 to 85.0 deg-C

Boiling Point

358.3℃ at 760 mmHg

Flash Point

170.5℃

Refractive Index

1.511

SMILES

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CC1=CC(=NC(=N1)S(=O)(=O)C)C

InChI

InChI=1S/C7H10N2O2S/c1-5-4-6(2)9-7(8-5)12(3,10)11/h4H,1-3H3

InChIKey

ZHPSNGCLCHWTRG-UHFFFAOYSA-N

LogP

0.49693999999999994

Topological Polar Surface Area

59.92 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

235

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Methanesulfonyl-4,6-dimethylpyrimidine
STR08654
UNII-85VAF5UF4F
2-methanesulfonyl-4,6-dimethy-pyrimidine
4,6-dimethyl-2-(methylsulphonyl)pyrimidine
ZHPSNGCLCHWTRG-UHFFFAOYSA-N
Z1201622440
D3699
FT-0639232
4,6-dimethyl-2-methanesulphonyl pyrimidine
pyrimidine, 4,6-dimethyl-2-(methylsulfonyl)-
4,6-dimethyl-2-methylsulfonyl pyrimidine
4,6-Dimethyl-2-methylsulfonylpyrimidine
BCP12397
2-methane-sulfonyl-4,6-dimethyl-pyrimidine
EN300-3452848
AM20090551
AC-2954
2-METHANESULFONYL-4,6-DIMETHYL-PYRIMIDINE
W-202442
35144-22-0
MS-0453
4,6 -dimethyl-2-methylsulfonylpyrimidine
SCHEMBL1051087
DTXSID10378242
CS-W003098
AKOS005107489
SY003418
85VAF5UF4F
MFCD03788286
A6172

MDL Number

MFCD03788286

Customs Code

2933599090

FAQ

What is Ambrisentan Impurity 3 (CAS: 35144-22-0)?

Ambrisentan Impurity 3, with the CAS number 35144-22-0, is a trace compound found during the synthesis of ambrisentan, a selective endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It is typically characterized by its molecular structure and may have specific physical and chemical properties that differ from the main drug substance.

What are the main uses of Ambrisentan Impurity 3 (CAS: 35144-22-0)?

Ambrisentan Impurity 3 is primarily used in pharmaceutical research and quality control to identify and quantify impurities during the production of ambrisentan. It may also be relevant in the development of analytical methods for drug purity assessment and regulatory compliance in drug manufacturing processes.

Is Ambrisentan Impurity 3 (CAS: 35144-22-0) safe?

Ambrisentan Impurity 3 is generally considered safe in trace amounts, but its safety profile depends on exposure levels and handling conditions. Proper protective measures, such as using gloves and ensuring good ventilation, should be taken during handling to minimize potential risks. Safety standards for impurities are usually governed by pharmaceutical regulations and guidelines.

How should Ambrisentan Impurity 3 (CAS: 35144-22-0) be stored?

Ambrisentan Impurity 3 should be stored in a cool, dry, and dark place, preferably at temperatures below 25°C. It is important to maintain low humidity levels and protect it from light exposure. The compound should be kept in a sealed, airtight container to ensure stability and prevent contamination.