2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate

Basic Information

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CAS Number

351369-12-5

Molecular Formula

C9H17FN2O2

Molecular Weight

204.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Basic Physical Properties

Boiling Point

295 ºC

Flash Point

132 ºC

SMILES

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CC(C)(C)OC(=O)NC1CNCC1F

InChI

InChI=1S/C9H17FN2O2/c1-9(2,3)14-8(13)12-7-5-11-4-6(7)10/h6-7,11H,4-5H2,1-3H3,(H,12,13)

InChIKey

BZSDDSIFAGBZLT-UHFFFAOYSA-N

LogP

0.8210000000000001

Topological Polar Surface Area

50.36 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

215

Synonyms & References

English

TERT-BUTYL N-[(3R,4R)-4-FLUOROPYRROLIDIN-3-YL]CARBAMATE
TERT-BUTYL 4-FLUOROPYRROLIDIN-3-YLCARBAMATE
AS-50705
CS-0048067
A874751
tert-Butyl (4-fluoropyrrolidin-3-yl)carbamate
SY099072
SY130876
(3R,4S)-(3-Boc-amino)-4-fluoropyrrolidine
MFCD24368651
351369-12-5
SB12381
TERT-BUTYL (4-FLUORO-3-PYRROLIDINYL)CARBAMATE
P10920
SCHEMBL4519280
SB12384
169750-42-9
SB13121
(4-Fluoropyrrolidin-3-yl)carbamic acid tert-butyl ester
SB13123
tert-butyl N-[trans-4-fluoropyrrolidin-3-yl]carbamate
SY128728
(4-Fluoro-pyrrolidin-3-yl)-carbamic acid tert-butyl ester
SB12385
AKOS024076472
(3-Boc-amino)-4-fluoropyrrolidine
tert-butyl N-[cis-4-fluoropyrrolidin-3-yl]carbamate
(3S,4R)-N-Boc-4-fluoropyrrolidin-3-amine
Carbamic acid, N-[(3R,4S)-4-fluoro-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
tert-Butyl(4-fluoropyrrolidin-3-yl)carbamate
AMY23903

MDL Number

MFCD10566553

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate (CAS: 351369-12-5)?

2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate is a white crystalline solid with a molecular weight of approximately 219.2 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. This compound is reactive and can undergo hydrolysis under acidic or basic conditions. It has a melting point of 71-73°C.

How is 2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate (CAS: 351369-12-5) typically synthesized?

2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate is typically synthesized via a multi-step process involving the protection of a pyrrolidine ring, formation of an amide bond, and subsequent deprotection. The synthesis usually requires the use of specific reagents such as methyl chloroformate and fluoro-3-pyrrolidine carboxylic acid. The yield is generally around 70-80%.

What industries use 2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate (CAS: 351369-12-5)?

2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It can also be found in the polymer industry for modifying the properties of polymers and in the sensor industry for use in gas sensing applications.

What precautions should be taken when handling 2-Methyl-2-propanyl (4-fluoro-3-pyrrolidinyl)carbamate (CAS: 351369-12-5)?

When handling 2-Methyl-2-proanyl (4-fluoro-3-pyrrolidinyl)carbamate, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate chemical clean-up procedures, and the material safety data sheet (MSDS) should be consulted for specific handling instructions.