N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide | CAS No. 346663-56-7
N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide
Basic Information
CAS Number
346663-56-7
Molecular Formula
C12H10ClNOS
Molecular Weight
251.73 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 2-Thiopheneacetamide, N-(4-chlorophenyl)-
- N-(4-chlorophenyl)-2-thiophen-2-ylacetamide
- N-(4-chlorophenyl)-2-(2-thienyl)acetamide
- Cambridge id 6178789
- CHEMBL398095
- AB00103690-01
- N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide
- CXNUOYHNEAWBGS-UHFFFAOYSA-N
- HMS2346P04
- 346663-56-7
- WAY-299819
- SMR000070757
- Thiophene-2-acetamide, N-(4-chlorophenyl)-
- MLS000061897
- STK098556
- F2245-0180
- AKOS003264179
FAQ
What are the physical and chemical properties of N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide (CAS: 346663-56-7)?
N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide is a crystalline solid with a molecular weight of approximately 261.17 g/mol. It has a limited solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. The compound is relatively inert under normal conditions but can react with strong bases to form acetic acid and the corresponding amine. It is stable under acidic and neutral conditions but may decompose at high temperatures or in the presence of strong oxidizing agents.
How is N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide (CAS: 346663-56-7) typically synthesized?
N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide is usually synthesized by the condensation of 4-chlorobenzaldehyde with 2-thiophenecarboxaldehyde in the presence of a base like sodium hydroxide. The reaction takes place in an aprotic solvent such as dimethylformamide (DMF) and yields the compound in good to excellent yields (typically 70-90%). This synthesis method is selective and有助于合成工艺的优化和理解。
What industries use N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide (CAS: 346663-56-7)?
N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide is primarily used in the pharmaceutical industry for its potential as a precursor in drug synthesis. It is also utilized in the polymer industry for its ability to act as a crosslinking agent. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its chemical properties and stability.
What precautions should be taken when handling N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide (CAS: 346663-56-7)?
When handling N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be stored in a cool, dry place away from direct sunlight and sources of heat. Fume hoods should be used during handling to minimize exposure to vapors. In case of spill, it should be cleaned up using appropriate absorbent materials and properly disposed of according to local regulations. A Material Safety Data Sheet (MSDS) should always be available for reference.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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