N-(4-Hydroxyphenyl)acrylamide

Basic Information

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CAS Number

34443-04-4

Molecular Formula

C9H9NO2

Molecular Weight

163.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C=CC(=O)NC1=CC=C(C=C1)O

InChI

InChI=1S/C9H9NO2/c1-2-9(12)10-7-3-5-8(11)6-4-7/h2-6,11H,1H2,(H,10,12)

InChIKey

POVITWJTUUJBNK-UHFFFAOYSA-N

LogP

1.5166999999999997

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

171

Synonyms & References

English

n-hydroxyphenyl acrylamide
EINECS 252-026-9
SY288307
FT-0718553
N-(4-hydroxyphenyl)prop-2-enamide
SCHEMBL133445
N-(4-Hydroxy-phenyl)-acrylamide
ACRYLANILIDE, 4'-HYDROXY-
N-(4-Hydroxyphenyl)-2-propenamide
DTXSID00188014
NS00029664
34443-04-4
BRN 2638744
4'-Hydroxyacrylanilide
N-(4-Hydroxyphenyl)acrylamide
2-Propenamide, N-(4-hydroxyphenyl)-
MFCD01673905
CHEMBL1802303
2-Propenamide,N-(4-hydroxyphenyl)-
2-Propenamide, N-(4-hydroxyphenyl)- (9CI)
Acrylanilide, 4'-hydroxy-

MDL Number

MFCD01673905

FAQ

What are the physical and chemical properties of N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4)?

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is a colorless to white crystalline solid with a molecular weight of approximately 226.25 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive towards nucleophiles and can undergo polymerization under certain conditions.

How is N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) typically synthesized?

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is synthesized by the condensation of 4-hydroxybenzaldehyde with acrylamide. Commonly, this reaction is catalyzed by a Lewis acid like aluminum trichloride in an organic solvent such as chloroform. The yield is typically around 70-80%, with good selectivity towards the desired product.

What industries use N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4)?

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is used in the pharmaceutical industry for its UV absorbance properties, in polymer synthesis as a monomer, and in the production of sensors due to its photochemical reactivity. It also has applications in the semiconductor industry for its use in photolithography processes.

What precautions should be taken when handling N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4)?

When handling N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4), ensure proper ventilation and use in a fume hood due to its volatility. Personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat is essential. Avoid contact with skin and eyes. Spills should be handled with care using appropriate absorbents and disposed of according to local regulations. Always refer to a Material Safety Data Sheet (MSDS) for detailed safety information.