N-(4-Hydroxyphenyl)acrylamide(CAS: 34443-04-4)

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is a colorless to white crystalline solid with a molecular weight of approximately 226.25 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive towards nucleophiles and can undergo polymerization under certain conditions.

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is synthesized by the condensation of 4-hydroxybenzaldehyde with acrylamide. Commonly, this reaction is catalyzed by a Lewis acid like aluminum trichloride in an organic solvent such as chloroform. The yield is typically around 70-80%, with good selectivity towards the desired product.

N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4) is used in the pharmaceutical industry for its UV absorbance properties, in polymer synthesis as a monomer, and in the production of sensors due to its photochemical reactivity. It also has applications in the semiconductor industry for its use in photolithography processes.

When handling N-(4-Hydroxyphenyl)acrylamide (CAS: 34443-04-4), ensure proper ventilation and use in a fume hood due to its volatility. Personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat is essential. Avoid contact with skin and eyes. Spills should be handled with care using appropriate absorbents and disposed of according to local regulations. Always refer to a Material Safety Data Sheet (MSDS) for detailed safety information.