2-Iodothiophene

Basic Information

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CAS Number

3437-95-4

Molecular Formula

C4H3IS

Molecular Weight

210.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

−40 °C

Boiling Point

182°C

Refractive Index

n20/D 1.651(lit.)

SMILES

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C1=CSC(=C1)I

InChI

InChI=1S/C4H3IS/c5-4-2-1-3-6-4/h1-3H

InChIKey

ROIMNSWDOJCBFR-UHFFFAOYSA-N

LogP

2.3527000000000005

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

46.8

Safety Information

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GHS Hazard Pictograms

H302

H315

H317

H318

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Light Sensitive

Synonyms & References

English

SCHEMBL155532
AKOS015853948
2-IODOTHIOPHENE
NSC-1082
Thiophene, iodo-
FT-0612690
Z4KJ38KVA6
DTXSID0063026
MFCD00005424
EINECS 222-342-1
alpha-Iodothiophene
SY001504
2-iodo-thiophene
AC-4904
AM86883
F0001-1002
BIDD:GT0507
EN300-87368
2-iodo thiophene
.alpha.-Iodothiophene
2-Iodothiophene, 98%
STR02125
NSC1082
NS00029649
I0374
UNII-Z4KJ38KVA6
InChI=1/C4H3IS/c5-4-2-1-3-6-4/h1-3
149762-92-5
Q-101196
A15989
3437-95-4

MDL Number

MFCD00005424

Customs Code

29349990

FAQ

What are the physical and chemical properties of 2-Iodothiophene (CAS: 3437-95-4)?

2-Iodothiophene (CAS: 3437-95-4) is a colorless liquid with a molecular weight of approximately 192.7 g/mol. It has a density of around 1.33 g/cm³ and a boiling point of about 158°C. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. It is a reactive compound, particularly with nucleophiles and reducing agents.

How is 2-Iodothiophene (CAS: 3437-95-4) typically synthesized?

2-Iodothiophene (CAS: 3437-95-4) is typically synthesized by the reaction of thiophene with iodine in the presence of a Lewis acid catalyst such as aluminum chloride. This process allows for good yield and selectivity, making it a common method in synthetic chemistry.

What industries use 2-Iodothiophene (CAS: 3437-95-4)?

2-Iodothiophene (CAS: 3437-95-4) is primarily used in the pharmaceutical and polymer industries. It serves as a precursor in the synthesis of various drugs and is also utilized in the development of polymeric materials for electronic and optical applications.

What precautions should be taken when handling 2-Iodothiophene (CAS: 3437-95-4)?

When handling 2-Iodothiophene (CAS: 3437-95-4), it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood due to its volatility. Spills should be cleaned up immediately with appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.