Sugammadex | CAS No. 343306-71-8

Sugammadex

Basic Information

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CAS Number

343306-71-8

Molecular Formula

C72H104Na8O48S8

Molecular Weight

2178.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)O)O)C(=O)O

InChI

1S/C72H112O48S8.8Na/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90;;;;;;;;/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88);;;;;;;;/q;8*+1/p-8/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-;;;;;;;;/m1......../s1

InChIKey

KMGKABOMYQLLDJ-VKHHSAQNSA-F

LogP

-18.35920

Complexity

2790

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

sugammadex
Org 25969
UNII-361LPM2T56
Bridion
Sugammadex Sodium
ERJ6X2MXV7
Sugammadex sodium [USAN:JAN]
Bridion (TN)
Sugammadex sodium (JAN/USAN)
D05940
Octasodium 6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octakis-S-(2-carboxylatoethyl)-6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octathiocyclo-alpha-(1-4)-D-octaglucopyranoside
gamma-Cyclodextrin, 6A,6B,6C,6D,6E,7F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,7F,6G,6H-oct
A-cyclodextrin
Suggmadex Sodium
361LPM2T56
SUGAMMADEX [EMA EPAR]
Gamma-cyclodextrin, 6A,6B,6C,6D,6E,7F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,7F,6G,6H-octathio-
Sugammadex
DTXCID901324600
V03AB35
6,6',6'',6''',6'''',6''''',6'''''',6'''''''-OCTAKIS-S-(2-CARBOXYLATOETHYL)-6,6',6'',6''',6'''',6''''',6'''''',6'''''''-OCTATHIOCYCLO-alpha-(1->4)-D-OCTAGLUCOPYRANOSIDE
Sugammadex [USAN:INN:BAN]
6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-?-Cyclodextrin
SCHEMBL13917069
Sugammadex [INN]
SUGAMMADEX [MI]
CHEBI:90953
C74763
AC-35805
.GAMMA.-CYCLODEXTRIN, 6A,6B,6C,6D,6E,7F,6G,6H-OCTAKIS-S-(2-CARBOXYETHYL)-6A,6B,6C,6D,6E,7F,6G,6H-OCTATHIO-
6,6',6'',6''',6'''',6''''',6'''''',6'''''''-OCTAKIS-S-(2-CARBOXYLATOETHYL)-6,6',6'',6''',6'''',6''''',6'''''',6'''''''-OCTATHIOCYCLO-.ALPHA.-(1->4)-D-OCTAGLUCOPYRANOSIDE

MDL Number

MFCD09954145

FAQ

What are the physical and chemical properties of Sugammadex (CAS: 343306-71-8)?

Sugammadex is a beta-cyclodextrin derivative with a molecular weight of approximately 1200 g/mol. It is poorly soluble in water but soluble in ethanol. Sugammadex is highly reactive due to its beta-cyclodextrin structure, which can form inclusion complexes with various substances. It is a crystalline solid at room temperature.

How is Sugammadex (CAS: 343306-71-8) typically synthesized?

Sugammadex is synthesized through a multistep process involving the cyclodimerization of gamma-cyclodextrin in the presence of a catalyst, such as ethylene glycol. The process also includes protecting group methodologies to control the cyclodimerization reaction. The overall yield is around 50-70%.

What industries use Sugammadex (CAS: 343306-71-8)?

Sugammadex is primarily used in the pharmaceutical industry for the reversal of neuromuscular blockade induced by non-depolarizing muscle relaxants. It has limited applications in other industries as it is specifically developed and approved for clinical use.

What precautions should be taken when handling Sugammadex (CAS: 343306-71-8)?

When handling Sugammadex, it is important to wear appropriate personal protective equipment (PPE), such as gloves and safety glasses. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using standard spill procedures, and the storage area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.