Sunitinib Malate

Basic Information

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CAS Number

341031-54-7

Molecular Formula

C26H33FN4O7

Molecular Weight

532.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

225-238°C

Solubility

DMSO: >10mg/mL

SMILES

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CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

InChI

InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChIKey

LBWFXVZLPYTWQI-IPOVEDGCSA-N

LogP

2.2415400000000014

Topological Polar Surface Area

172.05999999999997 Å²

Hydrogen Bond Donor/Acceptor

6 / 11

Complexity

765

Safety Information

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Hazard Statement

H360 May damage fertility or the unborn child
Reproductive toxicity

H372 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Synonyms & References

English

D06402
HY-10255
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysuccinate
DTXSID4046492
PDGF TK antagonist
SUNITINIB MALATE [MI]
Tox21_112249_1
SUNITINIB MALATE [MART.]
J-019449
SU 011248
SU-011248 L-malate salt
Sunitinib malate, >=98% (HPLC)
HMS3261H09
1H-Pyrrole-3-carboxamide,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
SUNITINIB MALEATE
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide(S)-2-hydroxysuccinate
MFCD08282795
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
Sutent (TN)
UNII-LVX8N1UT73
SUNITINIB MALATE [ORANGE BOOK]
SU011248 L-malate salt
341031-54-7
CS-0177
Sutent
CCG-221818
1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
Tox21_500514
SU-11248J

MDL Number

MFCD08282795

FAQ

What is Sunitinib Malate (CAS: 341031-54-7)?

Sunitinib Malate (CAS: 341031-54-7) is a multi-targeted tyrosine kinase inhibitor used in cancer therapy. Its chemical formula is C27H31N7O10S·C4H6O4, and it is a white to off-white solid with good solubility in water. It is commonly used in pharmaceutical applications for its anti-cancer properties and is known for its ability to inhibit multiple receptor tyrosine kinases involved in tumor growth.

What are the main uses of Sunitinib Malate (CAS: 341031-54-7)?

Sunitinib Malate (CAS: 341031-54-7) is primarily used in oncology to treat various types of cancer, including gastrointestinal stromal tumors (GIST), renal cell carcinoma, and pancreatic neuroendocrine tumors. It is also used in research for studying kinase inhibition and in pharmaceutical development for drug formulation and clinical trials. As a synthetic compound, it has applications in drug discovery and targeted therapy.

Is Sunitinib Malate (CAS: 341031-54-7) safe?

Sunitinib Malate (CAS: 341031-54-7) is generally considered safe when used as prescribed in medical settings. However, it may cause side effects such as fatigue, nausea, and hypertension. Proper handling and use under medical supervision are essential to ensure safety. It is important to follow safety guidelines and protective measures to minimize risks during storage, transportation, and administration.

How should Sunitinib Malate (CAS: 341031-54-7) be stored?

Sunitinib Malate (CAS: 341031-54-7) should be stored in a cool, dry, and dark place, ideally at 20-25°C. It should be kept in a sealed container away from moisture and light to maintain its stability and potency. Proper storage conditions are crucial to ensure the compound remains effective and safe for use in pharmaceutical and research applications.