2-(2-Oxo-1-pyrrolidinyl)butanamide

Basic Information

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CAS Number

33996-58-6

Molecular Formula

C8H14N2O2

Molecular Weight

170.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

118-124°C

Boiling Point

395.9 °C at 760 mmHg

Density

1.168

Flash Point

193.2 °C

Refractive Index

1.518

SMILES

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CCC(C(=O)N)N1CCCC1=O

InChI

InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)

InChIKey

HPHUVLMMVZITSG-UHFFFAOYSA-N

LogP

-0.12729999999999986

Topological Polar Surface Area

63.400000000000006 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

203

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H411 Toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

(R)-Levetiracetam
HMS3657M11
Tox21_112273
FT-0670771
(+/-)-.ALPHA.-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE
alpha-Ethyl-2-oxo-1-pyrrolidineacetamide
HMS3369E01
B0215-473717
Tox21_112273_1
NCGC00165970-01
MFCD00868507
DB11868
NCGC00186028-02
(.+/-.)-.alpha.-Ethyl-2-oxo-1-pyrrolidineacetamide
DTXCID3026510
Etiracetamum [INN-Latin]
AKOS005066190
Q15408406
NS00076338
A822033
FT-0602577
HY-B0106A
230447L0GL
EN300-297582
etiracetam, R-isomer;Levetiracetam Impurity D;(R)-2-(2-Oxopyrrolidin-1-yl)butanamide
UCB-6474
BCP33705
CS-0016496
E98663
UNII-230447L0GL
UCB 6474

MDL Number

MFCD00867782

FAQ

What are the physical and chemical properties of 2-(2-Oxo-1-pyrrolidinyl)butanamide (CAS: 33996-58-6)?

2-(2-Oxo-1-pyrrolidinyl)butanamide is a white crystalline solid with a molecular weight of approximately 220.35 g/mol. It is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone. The compound exhibits good stability under normal storage conditions but is susceptible to hydrolysis in the presence of moisture. It is slightly basic with a pKa of around 7.5.

How is 2-(2-Oxo-1-pyrrolidinyl)butanamide (CAS: 33996-58-6) typically synthesized?

2-(2-Oxo-1-pyrrolidinyl)butanamide is typically synthesized via the condensation of butyramide with 2-pyrrolidone in the presence of a base such as triethylamine. The reaction is carried out in an aprotic solvent like dichloromethane, and the yield is generally high, around 85-90%. This method provides good control over the selectivity and quality of the product.

What industries use 2-(2-Oxo-1-pyrrolidinyl)butanamide (CAS: 33996-58-6)?

2-(2-Oxo-1-pyrrolidinyl)butanamide is used in the pharmaceutical industry as a precursor for the synthesis of certain biologically active compounds. It is also utilized in the production of polymers and as a reagent in chemical sensing applications. Additionally, it finds use in the semiconductor industry for specific chemical processes.

What precautions should be taken when handling 2-(2-Oxo-1-pyrrolidinyl)butanamide (CAS: 33996-58-6)?

When handling 2-(2-Oxo-1-pyrrolidinyl)butanamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area, preferably in a fume hood, to minimize inhalation risks. If a spill occurs, it should be cleaned up immediately using absorbent material and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.