2,2-Difluoro-1-propanol

Basic Information

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CAS Number

33420-52-9

Molecular Formula

C3H6F2O

Molecular Weight

96.08 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Physical State

Colorless to Yellow Liquid

Boiling Point

97-99

Refractive Index

n20/D 1.349

SMILES

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CC(CO)(F)F

InChI

InChI=1S/C3H6F2O/c1-3(4,5)2-6/h6H,2H2,1H3

InChIKey

CKLONJANQGBREW-UHFFFAOYSA-N

LogP

0.6339000000000001

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

44.1

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2,2-Difluoropropan-1-ol
AMY1243
A1-00495
MFCD07782150
EN300-188820
33420-52-9
2,2-Difluoropropanol
BCP15466
2 pound not2-Difluoro-propan-1-ol
NS00134254
AKOS005063322
SB36658
SY029658
A5958
FT-0630282
CS-W004324
1-Propanol, 2,2-difluoro-
2,2-Difluoro-1-propanol
2,2-difluoro-propan-1-ol
DTXSID20539226
J-506796
2,2-difluoropropan-1-ol
2,2-Difluoro-propan-1-ol

MDL Number

MFCD07782150

Customs Code

2905590090

FAQ

What are the physical and chemical properties of 2,2-Difluoro-1-propanol (CAS: 33420-52-9)?

2,2-Difluoro-1-propanol has a crystalline form and a molecular weight of approximately 120.02 g/mol. It is slightly soluble in water but miscible with many organic solvents. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. Its specific gravity is around 1.19 g/cm³ at 20°C. It is used in synthesis as a precursor for various fluorinated compounds due to its reactivity and stability under certain conditions.

How is 2,2-Difluoro-1-propanol (CAS: 33420-52-9) typically synthesized?

2,2-Difluoro-1-propanol is commonly synthesized via the reaction of acetone with hydrogen fluoride (HF) in the presence of a phase transfer catalyst like tetrabutylammonium fluoride (TBAF). This process typically involves a one-pot reaction under anhydrous conditions. The yield is generally high, and the selectivity is good for the desired product. The reaction is exothermic and requires careful temperature control to avoid side reactions.

What industries use 2,2-Difluoro-1-propanol (CAS: 33420-52-9)?

2,2-Difluoro-1-propanol is widely used in the pharmaceutical industry for the synthesis of fluorinated drugs due to its reactivity. It is also utilized in the polymer industry for the production of fluorinated polymers with enhanced properties. Additionally, the compound is employed in the sensor industry for its sensitivity to specific analytes and in the semiconductor industry for its use in etching and cleaning processes.

What precautions should be taken when handling 2,2-Difluoro-1-propanol (CAS: 33420-52-9)?

When handling 2,2-Difluoro-1-propanol, it is crucial to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources. Fume hoods should be used during handling to minimize exposure. In case of spillage, the area should be immediately cleaned up with appropriate absorbents, and the SDS (Safety Data Sheet) should be consulted for specific cleanup procedures. The compound is not a major fire hazard but should be handled with care due to its volatility and reactivity.