1-[4-(Trifluoromethyl)phenyl]methanamine

Basic Information

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CAS Number

3300-51-4

Molecular Formula

C8H8F3N

Molecular Weight

175.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

113°C/40mmHg

Refractive Index

n20/D 1.464(lit.)

SMILES

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C1=CC(=CC=C1CN)C(F)(F)F

InChI

InChI=1S/C8H8F3N/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-4H,5,12H2

InChIKey

PRDBLLIPPDOICK-UHFFFAOYSA-N

LogP

2.1641000000000004

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

136

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

(4-trifluoromethylphenyl)methanamine
(4-(trifluoromethyl)phenyl)methanamine
(4-(trifluoromethyl)phenyl) methanamine
4-(trifluoromethyl)-benzylamine
HMS1733E14
CK1119
NS00049612
alpha-Amino-alpha',alpha',alpha'-trifluoro-p-xylene
p-trifluoromethylbenzylamine
FT-0616924
AC-4177
4-Trifluoromethyl-benzylamine
Benzenemethanamine, 4-(trifluoromethyl)-
p-trifluoromethyl benzylamine
[4-(trifluoromethyl)benzyl]amine
P-(TRIFLUOROMETHYL)BENZYL AMINE
CS-W007523
U1H
1-[4-(trifluoromethyl)phenyl]methanamine
CHEMBL274193
FT-0654318
4-(Trifluoromethyl)benzylamine Hydrochloride, >/=98%
DTXSID60186637
AB01000853-01
(4-(trifluoromethyl)benzyl)amine
AB01000853-03
SCHEMBL108337
EN300-23486
4(trifluoromethyl)benzylamine
p-(Trifluoromethyl)benzylamine
4-trifluoromethyl-benzyl amine

MDL Number

MFCD00010220

Customs Code

2921499090

FAQ

What are the physical and chemical properties of 1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4)?

1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4) is a white crystalline solid with a molecular weight of approximately 221.11 g/mol. It has a low water solubility (0.01 g/L at 20°C) and is moderately soluble in organic solvents like methanol and acetonitrile. Chemically, it is stable but can react with strong acids and bases. It exhibits moderate reactivity in aromatic substitution reactions.

How is 1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4) typically synthesized?

1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4) is often synthesized through the N-amination of 4-(trifluoromethyl)benzoyl chloride using an amine in the presence of a suitable catalyst such as triethylamine. The reaction typically yields a high purity product with good selectivity and yield.

What industries use 1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4)?

1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4) finds applications in the pharmaceutical industry due to its potential as a precursor for drug synthesis. It is also used in the electronics industry for semiconductor applications and in polymer chemistry for the development of novel materials.

What precautions should be taken when handling 1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4)?

When handling 1-[4-(Trifluoromethyl)phenyl]methanamine (CAS: 3300-51-4), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood. Spills should be managed with absorbent materials and properly disposed of according to laboratory waste management guidelines. Always consult the Safety Data Sheet (SDS) for detailed handling information.