Diphenidol hydrochloride

Basic Information

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CAS Number

3254-89-5

Molecular Formula

C21H28ClNO

Molecular Weight

345.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

212-214°

Boiling Point

473.3°C at 760 mmHg

Flash Point

233.5 °C

SMILES

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C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl

InChI

InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H

InChIKey

AVZIYZHXZAYGJS-UHFFFAOYSA-N

LogP

4.610400000000004

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

307

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

SW197007-3
1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride
Yesdol
DS-1389
Celmidol
Diphenidol HCl
SR-01000721935
Cefadol
DIFENIDOL HYDROCHLORIDE [JAN]
Z57257314
.alpha.,.alpha.-Diphenyl-1-piperidinebutanol hydrochloride
DTXCID20108739
FT-0667646
HMS1568D06
difenidol hydrochloride
MFCD00151479
Diphenidol hydrochloride [USAN]
CHEBI:31481
2C64
Maniol
1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride
Ansmin
DIFENIDOL HYDROCHLORIDE (MART.)
DIPHENIDOL HYDROCHLORIDE [VANDF]
SK-478-A
1-Piperidinebutanol,.alpha.-diphenyl, hydrochloride
D2062
DIFENIDOL HYDROCHLORIDE [MART.]
DIPHENIDOL HYDROCHLORIDE [ORANGE BOOK]
DIFENIDOL HYDROCHLORIDE [WHO-DD]
1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride

MDL Number

MFCD00151479

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Diphenidol hydrochloride (CAS: 3254-89-5)?

Diphenidol hydrochloride (CAS: 3254-89-5) is a crystalline white powder with a molecular weight of approximately 322.72 g/mol. It has a solubility of about 17.5 mg/mL in water and is poorly soluble in organic solvents. Chemically, it is moderately reactive, particularly with bases, and can undergo hydrolysis under basic conditions. It is a weak acid due to the presence of the hydrochloride salt.

How is Diphenidol hydrochloride (CAS: 3254-89-5) typically synthesized?

Diphenidol hydrochloride is typically synthesized by reacting diphenidol (the parent compound) with hydrochloric acid. The reaction is usually conducted in an aqueous medium at room temperature, followed by crystallization from the reaction mixture. The yield is moderate to good, with selectivity towards the formation of the hydrochloride salt being high.

What industries use Diphenidol hydrochloride (CAS: 3254-89-5)?

Diphenidol hydrochloride (CAS: 3254-89-5) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of other compounds. It is also utilized in research and development for various applications, including in polymers for specific properties, and in the development of chemical sensors and semiconductors.

What precautions should be taken when handling Diphenidol hydrochloride (CAS: 3254-89-5)?

When handling Diphenidol hydrochloride (CAS: 3254-89-5), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure adequate ventilation and use a fume hood when handling the compound to avoid inhalation of dust. Spills should be managed with care, using absorbent materials and proper waste disposal procedures. Always refer to the SDS for detailed safety information and guidelines.