(2S)-Amino(4-hydroxyphenyl)acetic acid

Basic Information

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CAS Number

32462-30-9

Molecular Formula

C8H9NO3

Molecular Weight

167.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Solid

Melting Point

214°C(dec.)

Boiling Point

365.8 °C at 760 mmHg

Density

1.396 g/cm3

Flash Point

175 °C

Refractive Index

1.633

Specific Rotation

158 º (c=1% in 1M HCl)

SMILES

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C1=CC(=CC=C1C(C(=O)O)N)O

InChI

InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1

InChIKey

LJCWONGJFPCTTL-ZETCQYMHSA-N

LogP

0.4766

Topological Polar Surface Area

83.55 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

164

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(S)-Amino-(4-hydroxyphenyl)acetic acid
4-hydroxyphenylglycine, (s)-
EINECS 251-061-7
DTXSID3046403
CAS-32462-30-9
L-(+)-A-4-HYDROXYPHENYLGLYCINE
DB04291
CS-W018812
Oxfenicine [USAN:INN:BAN]
HY-W018026
D05292
Tox21_112144_1
L-(+)-2-(4-Hydroxyphenyl)glycine
DS-11081
(2s)-Amino(4-Hydroxyphenyl)Acetic Acid
LJCWONGJFPCTTL-ZETCQYMHSA-N
EN300-198950
(S)-(+)-2-Amino-2-(4-hydroxyphenyl)acetic Acid
Q27095113
UNII-9YH0WH2Z02
Benzeneacetic acid, alpha-amino-4-hydroxy-, (S)-
Z1255364887
(S)-4-hydroxyphenylglycine
9YH0WH2Z02
Benzeneacetic acid, alpha-amino-4-hydroxy-, (alphaS)-
NCGC00344518-01
L-P-HYDROXYPHENYGLYCINE
L-Hydroxyphenylglycine
Oxfenicina
Oxfenicina [INN-Spanish]
NS00070321

MDL Number

MFCD00065932

FAQ

What are the physical and chemical properties of (2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9)?

(2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9) is a white to off-white crystalline solid with a molecular weight of approximately 194.22 g/mol. It is slightly soluble in water and has a pKa value of about 2.6. It is reactive towards basic conditions and can undergo hydrolysis under acidic conditions. It is an important intermediate in the synthesis of various pharmaceuticals and biologically active compounds.

How is (2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9) typically synthesized?

(2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9) can be synthesized by the reduction of o-hydroxybenzaldehyde using sodium borohydride. The yield is typically around 80%, and the reaction is carried out under mild conditions. The product is then purified by recrystallization from ethanol or methanol.

What industries use (2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9)?

(2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also used in the production of polymers and as a building block for the development of sensors and semiconductors in the electronics industry.

What precautions should be taken when handling (2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9)?

When handling (2S)-Amino(4-hydroxyphenyl)acetic acid (CAS: 32462-30-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The material should be handled in a well-ventilated area or a fume hood to avoid inhalation of dust. Spills should be cleaned up immediately using absorbent paper, and the material should be stored in a cool, dry place away from direct sunlight. Safety data sheets (SDS) should be consulted for any specific handling instructions and emergency procedures.