(Trimethylsilyl)methanol | CAS No. 3219-63-4

Q: What regulatory guidelines apply to (Trimethylsilyl)methanol (CAS: 3219-63-4)?

(Trimethylsilyl)methanol (CAS: 3219-63-4) falls under the scope of the GHS (Globally Harmonized System of Classification and Labelling of Chemicals) for classification and labelling. It is also subject to REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) regulations in the EU, which require manufacturers and importers to register and evaluate the substance for safety. In the U.S., FDA and EPA have specific requirements for handling and use in pharmaceutical and industrial applications, respectively.

Q: Are there alternatives to (Trimethylsilyl)methanol (CAS: 3219-63-4) in synthesis?

There are several alternatives to (Trimethylsilyl)methanol (CAS: 3219-63-4) in synthesis, including other silylating agents like trimethylchlorosilane (TMCS), tert-butyldimethylsilyl triflate (TBDMSOTf), and other alcohols such as tert-butanol. These alternatives can be chosen based on the specific reaction conditions and desired properties of the final product.

Q: What is the market or research trend for (Trimethylsilyl)methanol (CAS: 3219-63-4)?

The market for (Trimethylsilyl)methanol (CAS: 3219-63-4) is steadily growing due to its widespread use in organic synthesis, particularly in protecting groups and as a silylating agent. Research trends are focusing on its application in pharmaceuticals, biotechnology, and material sciences. Additionally, there is increasing interest in its use as a green and sustainable reagent, leading to ongoing studies on its environmental impact and potential for safer alternatives.

Q: How should waste containing (Trimethylsilyl)methanol (CAS: 3219-63-4) be handled?

Waste containing (Trimethylsilyl)methanol (CAS: 3219-63-4) should be collected in appropriate containers and stored separately. Incineration is a common method for disposal, provided it is conducted in an appropriately licensed facility to comply with environmental regulations. Alternatively, professional waste disposal services can be utilized, ensuring the waste is handled in accordance with local and national disposal guidelines to minimize environmental impact and ensure safety.

(Trimethylsilyl)methanol

Basic Information

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CAS Number

3219-63-4

Molecular Formula

C4H12OSi

Molecular Weight

104.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

<0°C

Boiling Point

121°C

Water Solubility

Fully miscible in water.

Refractive Index

n20/D 1.419(lit.)

SMILES

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C[Si](C)(C)CO

InChI

InChI=1S/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3

InChIKey

ZQKNBDOVPOZPLY-UHFFFAOYSA-N

LogP

0.8560999999999999

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

37.3

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

EN300-1707856
SCHEMBL442088
Trimethylsilylmethanol
InChI=1/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3
ZQKNBDOVPOZPLY-UHFFFAOYSA-
Trimethylhydroxymethylsilane
MFCD00004596
AKOS015840042
4-04-00-03876 (Beilstein Handbook Reference)
Methanol, 1-(trimethylsilyl)-
BS-27999
NSC 96777
UNII-E19993083K
Trimethylsilylmethanol_RaGuSa
Hydroxymethyltrimethylsilane
s12036
trimethylsilanyl-methanol
(Trimethylsilyl)methanol purum
NS00046275
C4H12OSi
E19993083K
(Trimethylsilyl)methanol
DTXSID1062912
1-(TRIMETHYLSILYL)METHANOL
AMY36454
NSC96777
BP-12702
BRN 1731486
FT-0608324
A821196
1-Trimethylsilylmethanol

MDL Number

MFCD00004596

Customs Code

2931900090

FAQ

What regulatory guidelines apply to (Trimethylsilyl)methanol (CAS: 3219-63-4)?

(Trimethylsilyl)methanol (CAS: 3219-63-4) falls under the scope of the GHS (Globally Harmonized System of Classification and Labelling of Chemicals) for classification and labelling. It is also subject to REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) regulations in the EU, which require manufacturers and importers to register and evaluate the substance for safety. In the U.S., FDA and EPA have specific requirements for handling and use in pharmaceutical and industrial applications, respectively.

Are there alternatives to (Trimethylsilyl)methanol (CAS: 3219-63-4) in synthesis?

There are several alternatives to (Trimethylsilyl)methanol (CAS: 3219-63-4) in synthesis, including other silylating agents like trimethylchlorosilane (TMCS), tert-butyldimethylsilyl triflate (TBDMSOTf), and other alcohols such as tert-butanol. These alternatives can be chosen based on the specific reaction conditions and desired properties of the final product.

What is the market or research trend for (Trimethylsilyl)methanol (CAS: 3219-63-4)?

The market for (Trimethylsilyl)methanol (CAS: 3219-63-4) is steadily growing due to its widespread use in organic synthesis, particularly in protecting groups and as a silylating agent. Research trends are focusing on its application in pharmaceuticals, biotechnology, and material sciences. Additionally, there is increasing interest in its use as a green and sustainable reagent, leading to ongoing studies on its environmental impact and potential for safer alternatives.

How should waste containing (Trimethylsilyl)methanol (CAS: 3219-63-4) be handled?

Waste containing (Trimethylsilyl)methanol (CAS: 3219-63-4) should be collected in appropriate containers and stored separately. Incineration is a common method for disposal, provided it is conducted in an appropriately licensed facility to comply with environmental regulations. Alternatively, professional waste disposal services can be utilized, ensuring the waste is handled in accordance with local and national disposal guidelines to minimize environmental impact and ensure safety.