1-Acetyl-4-piperidinone

Basic Information

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CAS Number

32161-06-1

Molecular Formula

C7H11NO2

Molecular Weight

141.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Powder

Boiling Point

218 °C

Water Solubility

Soluble in water. Insoluble in acetic acid.

Refractive Index

n20/D 1.503(lit.)

SMILES

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CC(=O)N1CCC(=O)CC1

InChI

InChI=1S/C7H11NO2/c1-6(9)8-4-2-7(10)3-5-8/h2-5H2,1H3

InChIKey

NNFOVLFUGLWWCL-UHFFFAOYSA-N

LogP

0.1978000000000002

Topological Polar Surface Area

37.38 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

155

Synonyms & References

English

1-Acetyl-4-piperidinone #
F0001-0960
N-Acetylpiperidin-4-one
A26634
1-Acetyl-4-piperidinone
CS-W018303
n-acetyl4-piperidone
NS00058686
EN300-15627
1-acetyl-4-oxopiperidine
SCHEMBL137219
1-acetyl-piperidin-4-one
SY011035
1-Acetyl-4-piperidone, 94%
AM20080584
4-Piperidinone, 1-acetyl-
DTXSID10871369
AKOS000203574
MFCD00006190
Z33618658
1-Acetylpiperid-4-one
AS-17883
AI3-39159
1-acetyl-piperdin-4-one
SB42923
32161-06-1
FT-0753323
3211-06-1
1-Acetyl-4-piperidone
EINECS 250-937-6
N-ACETYL-4-PIPERIDINONE

MDL Number

MFCD00006190

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 1-Acetyl-4-piperidinone (CAS: 32161-06-1)?

1-Acetyl-4-piperidinone (CAS: 32161-06-1) is a colorless crystalline solid with a molecular weight of approximately 146.21 g/mol. It has a solubility of about 2.3 g/L in water. It is moderately reactive with amine groups and can undergo various transformations. It is soluble in common organic solvents like ethanol and acetone.

How is 1-Acetyl-4-piperidinone (CAS: 32161-06-1) typically synthesized?

1-Acetyl-4-piperidinone (CAS: 32161-06-1) is typically synthesized via the condensation of acetic anhydride with 4-piperidone. The reaction is usually performed under basic conditions with a catalyst like pyridine to improve yield and selectivity. The process typically yields a product with a purity of over 95%.

What industries use 1-Acetyl-4-piperidinone (CAS: 32161-06-1)?

1-Acetyl-4-piperidinone (CAS: 32161-06-1) is primarily used in the pharmaceutical and polymer industries. It serves as a precursor for the synthesis of various drug intermediates and is also used in the preparation of certain polymers due to its reactive functional groups.

What precautions should be taken when handling 1-Acetyl-4-piperidinone (CAS: 32161-06-1)?

Handling 1-Acetyl-4-piperidinone (CAS: 32161-06-1) requires the use of proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. Spills should be handled using appropriate spill kits and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.