Axitinib | CAS No. 319460-85-0

Axitinib

Basic Information

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CAS Number

319460-85-0

Molecular Formula

C22H18N4OS

Molecular Weight

386.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

211-214°C

Boiling Point

668.9°C at 760 mmHg

Solubility

DMSO: ≥8mg/mL

SMILES

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CNC(=O)c1ccccc1Sc1ccc2c(c1)[nH]nc2/C=C/c1ccccn1

InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

InChIKey

RITAVMQDGBJQJZ-FMIVXFBMSA-N

LogP

4.6391000000000036

Topological Polar Surface Area

70.67 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Synonyms & References

English

Axitinib
Axitinib (usan)
D03218
Axitinib(AG 013736)
Axtinib
N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzaMide
Inlyta
Axitinib (TINIBS)
(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
[14C]-Axitinib
Afatinib
AG-010376
Axitinib (AG-013736, Inlyta®)
&nbsp
AG013736
AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
AVERMECTINB
AG-013736
N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide

MDL Number

MFCD09837898

Customs Code

2933990090

FAQ

What is Axitinib (CAS: 319460-85-0)?

Axitinib is a small molecule kinase inhibitor with the chemical formula C15H18N4O2. It is known for its selective targeting of vascular endothelial growth factor (VEGF) receptors, making it a valuable compound in pharmaceutical research. Axitinib is a white to off-white solid at room temperature and has good solubility in organic solvents.

What are the main uses of Axitinib (CAS: 319460-85-0)?

Axitinib is primarily used in the treatment of certain types of cancer, particularly renal cell carcinoma. It functions as a targeted therapy by inhibiting the growth of blood vessels that supply tumors, thereby slowing their progression. Additionally, it is used in research for studying angiogenesis and developing new anticancer drugs.

Is Axitinib (CAS: 319460-85-0) safe?

Axitinib is generally considered safe when used under medical supervision, but it may cause side effects such as hypertension, fatigue, and gastrointestinal issues. Proper handling and adherence to safety guidelines are essential during its use. It is classified as a pharmaceutical compound with established safety standards for therapeutic applications.

How should Axitinib (CAS: 319460-85-0) be stored?

Axitinib should be stored in a cool, dry, and dark place, ideally at 20–25°C. It is recommended to keep it in a sealed container to prevent moisture and contamination. Avoid exposure to light and ensure proper ventilation to maintain its stability and efficacy over time.