Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate | CAS No. 31883-05-3

Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate

Basic Information

CAS Number

31883-05-3

Molecular Formula

C22H25N3O4S

Molecular Weight

427.53 g/mol

AD

Basic Physical Properties

Melting Point

156-157°

Boiling Point

625°C at 760 mmHg

Density

1.315

Flash Point

331.8°C

Refractive Index

1.639

CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4

InChI

InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)

InChIKey

FUBVWMNBEHXPSU-UHFFFAOYSA-N

LogP

4.106600000000003

pKa

6.4(at 25℃)

Topological Polar Surface Area

71.11 Ų

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

601

Synonyms & References

English

  • Moracizine
  • C22H25N3O4S
  • Oprea1_701257
  • NCGC00016809-04
  • Moracizinum [INN-Latin]
  • BIDD:GT0499
  • G 214
  • ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate
  • MORICIZINE [MI]
  • 2GT1D0TMX1
  • GTPL7244
  • Prestwick2_001051
  • Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate
  • NCGC00074074-03
  • Moracizine (INN)
  • AB00514710
  • FT-0630560
  • DB00680
  • EN300-18530976
  • MORICIZINE
  • EINECS 250-854-5
  • MLS001201823
  • NS00029189
  • N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}ethoxycarboximidic acid
  • CARBAMIC ACID, [10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-, ETHYL ESTER
  • EN-313 FREE BASE
  • CAS-31883-05-3
  • Q904071
  • DTXSID4023335
  • A853599
  • MORACIZINE [WHO-DD]

MDL Number

MFCD00336543

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3)?

Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3) is a crystalline solid with a molecular weight of approximately 436.58 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and acetonitrile. The compound shows moderate reactivity with bases and is stable under acidic conditions. It exhibits a characteristic melting point of 205-208°C.

How is Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3) typically synthesized?

Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3) is typically synthesized via the condensation of ethyl phenothiazine-2-carboxylate with 3-(4-morpholinyl)propanoyl chloride. The reaction requires a base such as triethylamine and proceeds with good yield. The product can be isolated by recrystallization from a suitable solvent.

What industries use Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3)?

Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3) is primarily used in the pharmaceutical industry for its potential as an antipsychotic agent. It also has applications in the development of sensors and materials due to its unique chemical properties.

What precautions should be taken when handling Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3)?

When handling Ethyl {10-[3-(4-morpholinyl)propanoyl]-10H-phenothiazin-2-yl}carbamate (CAS: 31883-05-3), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure adequate ventilation and use a fume hood during operations. Spills should be handled with absorbent material and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling instructions.

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