3-Chloro-5-methyl-2-pyridinamine

Basic Information

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CAS Number

31430-41-8

Molecular Formula

C6H7ClN2

Molecular Weight

142.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

58.0 to 62.0 deg-C

Boiling Point

231.6 ℃ at 760 mmHg

Density

1.26

Flash Point

93.9 °C

Refractive Index

1.592

SMILES

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CC1=CC(=C(N=C1)N)Cl

InChI

InChI=1S/C6H7ClN2/c1-4-2-5(7)6(8)9-3-4/h2-3H,1H3,(H2,8,9)

InChIKey

COTHZSSUQJRBQH-UHFFFAOYSA-N

LogP

1.6256199999999998

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

97.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

AC-6265
A1-00135
SY037086
AS-30455
SCHEMBL118541
FT-0658649
DTXSID40482442
2-Amino-3-chloro-5-picoline (2-Amino-3-chloro-5-methylpyridine)
CS-0046207
2-Amino-3-chloro-5-methylpyridine
2-Pyridinamine, 3-chloro-5-methyl-
31430-41-8
6-Amino-5-chloro-3-picoline
3-CHLORO-5-METHYLPYRIDIN-2-AMINE
MFCD07368858
A820848
EN300-202749
3-chloranyl-5-methyl-pyridin-2-amine
doi:10.14272/COTHZSSUQJRBQH-UHFFFAOYSA-N.1
COTHZSSUQJRBQH-UHFFFAOYSA-N
3-Chloro-5-methylpyridine-2-ylamine
3-chloro-5-methyl-2-pyridinamine
AB32106
2-Amino-3-chloro-5-picoline
AMY6217
AKOS006340940
3-Chloro-5-methyl-2-pyridinamine, AldrichCPR
3-chloro-5-methylpyridin-2-amine
C6H7ClN2
2-Amino-3-chlor-5-methyl-pyridin
2-Amino-3-chlor-5-picolin

MDL Number

MFCD07368858

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8)?

3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8) is a crystalline solid with a molecular weight of approximately 173.59 g/mol. It has a faint pyridine-like odor. This compound is moderately soluble in water and highly soluble in organic solvents like methanol and ethanol. It shows basic properties due to the presence of the amine group. The compound is relatively stable but can react with strong acids or bases. It is commonly used in organic synthesis and medical research.

How is 3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8) typically synthesized?

3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8) can be synthesized through a multistep process involving the reaction of 5-chloro-2-pyridinemethanol with methyl iodide in the presence of a base such as sodium hydride. The reaction is typically carried out in an aprotic solvent like dimethylformamide (DMF) at room temperature. The yield can be improved by optimizing the reaction conditions and using appropriate catalysts.

What industries use 3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8)?

3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8) is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It is also utilized in the polymer industry as a precursor to develop functionalized polymers. Additionally, it finds applications in the sensor technology and as a reagent in organic synthesis. Its versatility makes it a valuable compound in various sectors.

What precautions should be taken when handling 3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8)?

When handling 3-Chloro-5-methyl-2-pyridinamine (CAS: 31430-41-8), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to minimize exposure to vapors. Proper storage in a cool, dry place away from heat and ignition sources is required. In case of spill, it should be cleaned up immediately with appropriate absorbents and reported to a supervisor. Always refer to the Safety Data Sheet (SDS) for detailed safety information.