(2R)-Hydroxy(4-methylphenyl)acetic acid

Basic Information

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CAS Number

31284-89-6

Molecular Formula

C9H10O3

Molecular Weight

166.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

130-133°C

Specific Rotation

-154° (c=1 in methanol)

SMILES

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CC1=CC=C(C=C1)C(C(=O)O)O

InChI

InChI=1S/C9H10O3/c1-6-2-4-7(5-3-6)8(10)9(11)12/h2-5,8,10H,1H3,(H,11,12)/t8-/m1/s1

InChIKey

SFGURAWGCAPHON-MRVPVSSYSA-N

LogP

1.11302

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

159

Safety Information

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GHS Hazard Pictograms

H318

Hazard Statement

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Light Sensitive

Synonyms & References

English

31284-89-6
(R)-4-Methylmandelic acid
(R)-Para-methylmandelic acid
(R)-alpha-Hydroxy(4-methylphenyl)acetic acid
E79455
(R)-(-)-4-Methylmandelic acid, 98%, ee 97%
(R)-4-Methylmandelic acid, ChiPros(R), produced by BASF, 98%
(R)-(-)-4-Methylmandelic acid
CS-0186127
(R)-2-Hydroxy-2-(p-tolyl)acetic acid
4-Methyl-D-mandelic acid
(2R)-2-hydroxy-2-(4-methylphenyl)acetic acid
MFCD00798433
AKOS025310775
(R)-2-hydroxy-2-p-tolylacetic acid
SCHEMBL366066
AS-17448
2-Hydroxy-2-(4-methylphenyl)acetic acid
(2R)-HYDROXY(5-METHYLPHENYL)ACETICACID
(4-methylphenyl)(hydroxy)acetic acid
(4-Methylphenyl)hydroxyacetic acid
(R)-(-)-4-Methylmandelic acid,ChiPros
(R)-PARA-METHYLMANDELIC ACID
2-hydroxy-2-(p-tolyl)acetic acid
2-p-tolyl-2-hydroxyethanoic acid
4-Methylmandelic acid
D-4-methyl-mandelic acid
Hydroxy(4-methylphenyl)acetic acid
p-methylmandelic acid
RARECHEM AL BO 1450

MDL Number

MFCD00798433

FAQ

What regulatory guidelines apply to (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6)?

The (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) is regulated under GHS classification as a skin and eye irritant. It falls under REACH regulations for chemical identification, safety data sheets, and registration. FDA and EPA have requirements for its use in pharmaceutical and agricultural applications respectively, ensuring compliance with Good Manufacturing Practices (GMP) and Environmental Protection Agency guidelines.

Are there alternatives to (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) in synthesis?

There are several alternatives to (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) in synthesis, including (2S)-Hydroxy(4-methylphenyl)acetic acid, which is a stereoisomer. Common alternative reagents include hydroxybenzoic acid derivatives and other phenolic acids that can be used as precursors or intermediates. These alternatives can offer similar functionalities or improved properties in specific applications.

What is the market or research trend for (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6)?

The market for (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) is driven by its applications in pharmaceuticals and cosmetics. Research trends focus on its potential use as a skin care ingredient due to its antioxidant and anti-inflammatory properties. Emerging studies are exploring its role in drug delivery systems and its effectiveness in treating dermatological conditions. Market trends indicate increasing demand from the personal care and pharmaceutical sectors.

How should waste containing (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) be handled?

Waste containing (2R)-Hydroxy(4-methylphenyl)acetic acid (CAS: 31284-89-6) should be collected in appropriate containers and stored in a secure, well-ventilated area. Incineration is a common disposal method, but professional waste disposal services should be used to ensure compliance with environmental regulations. Precautions include proper handling to avoid skin and eye contact, and adherence to local waste management guidelines to prevent environmental contamination.