Deferiprone | CAS No. 30652-11-0

Deferiprone

Basic Information

View in Editor

CAS Number

30652-11-0

Molecular Formula

C7H9NO2

Molecular Weight

139.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

260°C(dec.)

Boiling Point

232.9℃ at 760 mmHg

Refractive Index

1.4800 (estimate)

SMILES

View in Editor

CC1=C(C(=O)C=CN1C)O

InChI

InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

InChIKey

TZXKOCQBRNJULO-UHFFFAOYSA-N

LogP

0.39931999999999984

pKa

pKa1 3.3, pKa2 9.7(at 25℃)

Topological Polar Surface Area

42.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

228

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)

Synonyms & References

English

FT-0606424
BCP09606
1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone
Tox21_112429
CHEBI:68554
PL-1
HSDB 8335
deferiprone
Deferidone
Deferiprone (INN)
NCGC00090548-01
SR-01000721891-4
DEFERIPRONE [ORANGE BOOK]
3-Hydroxy-1,2-dimethyl-4-pyridinone
TZXKOCQBRNJULO-UHFFFAOYSA-
TZXKOCQBRNJULO-UHFFFAOYSA-N
DEFERIPRONE [INN]
4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
DEFERIPRONE [USAN]
SCHEMBL94474
NS00005705
3-hydroxy-1,2-dimethylpyridin-4(1H)-one
DS-5493
SY052576
Deferiprone (USAN/INN)
CP-20
Deferipronum
HK-1
Ferriprox
1,2-Dimethyl-3-hydroxypyridine-4-one
CS-5240

MDL Number

MFCD00134497

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Deferiprone (CAS: 30652-11-0)?

Deferiprone is a crystalline compound with a molecular weight of approximately 316.3 g/mol. It is poorly soluble in water but soluble in organic solvents. Chemically, it is reactive towards bases and oxidizing agents. It is mainly used in the treatment of iron overload and has limited solubility, making it challenging to formulate for oral administration without solubilizing agents.

How is Deferiprone (CAS: 30652-11-0) typically synthesized?

Deferiprone is typically synthesized through a multi-step process involving condensation reactions, amidation, and ring formation. Common methods include the use of 1,2-diaminopropane and 2,2'-iminodiethanoyl chloride as starting materials. The synthesis involves the formation of key intermediates and final coupling reactions to yield the target compound with good yields and selectivity.

What industries use Deferiprone (CAS: 30652-11-0)?

Deferiprone is primarily used in the pharmaceutical industry for the treatment of iron overload disorders. It is also relevant in academic research for studying iron metabolism and its effects on various cell functions. Although not widely used in other industries, its applications in biotechnology and potential use in drug screening platforms make it of interest in these sectors.

What precautions should be taken when handling Deferiprone (CAS: 30652-11-0)?

When handling Deferiprone, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage to ensure safe laboratory practices.