5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]- | CAS No. 302964-08-5

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Basic Information

CAS Number

302964-08-5

Molecular Formula

C16H13Cl2N5OS

Molecular Weight

394.28 g/mol

AD

Basic Physical Properties

Melting Point

333-335°C

Clc1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(n1)C

InChI

InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)

InChIKey

LMXUWARKUIELGT-UHFFFAOYSA-N

LogP

4.852640000000002

Topological Polar Surface Area

79.8 Ų

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

474

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H332 Harmful if inhaled
Acute toxicity, inhalation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
  • Dasatinib Int N-1
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide
  • N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]
  • CAY10697
  • N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide
  • 2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
  • 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-
  • 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
  • 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
  • Dasatinib Intermediate
  • N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide]-
  • 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

MDL Number

MFCD11045075

Customs Code

2934100090

FAQ

What is 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino] (CAS: 302964-08-5)?

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino] (CAS: 302964-08-5) is a chemical compound containing a thiazole ring and a pyrimidine ring. It is classified as a heterocyclic amide and is known for its potential applications in medicinal chemistry. The compound has a molecular formula of C16H14Cl2N4O and is typically a white to off-white solid with a melting point around 190–192°C.

What are the main uses of 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino] (CAS: 302964-08-5)?

This compound is primarily used in pharmaceutical research for the development of antiviral and anticancer drugs. It is also employed in organic synthesis as a building block for more complex molecules. Due to its structural features, it may be relevant in drug design and molecular biology studies, particularly in the context of nucleoside analogs and kinase inhibitors.

Is 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino] (CAS: 302964-08-5) safe?

Safety data for this compound is limited, but it is generally considered hazardous due to its chemical structure. Proper handling, including the use of protective gloves and eye wear, is recommended. It should be stored in a well-ventilated area and handled with care to avoid exposure. Always follow standard laboratory safety protocols when working with this compound.

How should 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino] (CAS: 302964-08-5) be stored?

This compound should be stored in a cool, dry, and light-protected environment, ideally at 2–8°C. It is best kept in a sealed container to prevent moisture and contamination. Due to its potential reactivity, it should be stored away from incompatible substances such as strong oxidizers and acids. Always ensure proper ventilation during storage and handling.

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