N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide | CAS No. 302962-49-8

N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide

Basic Information

CAS Number

302962-49-8

Molecular Formula

C22H26ClN7O2S

Molecular Weight

488.02 g/mol

AD

Basic Physical Properties

Physical State

Powder

Melting Point

275-286°C

CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO

InChI

InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChIKey

ZBNZXTGUTAYRHI-UHFFFAOYSA-N

LogP

3.3135400000000015

Topological Polar Surface Area

106.50999999999999 Ų

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

642

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • DASATINIB [WHO-DD]
  • NCGC00181129-02
  • NSC759877
  • DB01254
  • n-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide
  • n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
  • AB01273956_03
  • BMS-354825-03
  • DASATINIB [INN]
  • D03658
  • DTXCID2020979
  • Dasatinib (BMS-354825)
  • HMS3244B05
  • BCP01797
  • Tox21_112736_1
  • HY-10181
  • BRD-K49328571-001-07-7
  • 302962-49-8
  • 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-
  • CHEMBL1421
  • ZBNZXTGUTAYRHI-UHFFFAOYSA-N
  • AB01273956-01
  • AB01273956-02
  • HMS3265C19
  • Dasatinib (JAN/INN)
  • Tox21_112736
  • CAS-302962-49-8
  • NSC-800087
  • Dasatinib anhydrous
  • BMS 35482513
  • cid_3062316

MDL Number

MFCD11046566

FAQ

What is N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8)?

N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8) is a complex organic compound with potential pharmaceutical applications. It contains a thiazole ring, a pyrimidine ring, and a piperazine group, making it a candidate for drug development. The compound is known for its structural complexity and is often used in research settings for studying biological activity.

What are the main uses of N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8)?

This compound is primarily used in pharmaceutical research for the development of drugs targeting specific biological pathways. It may also find applications in agrochemicals and materials science due to its versatile chemical structure. Its use in drug discovery is driven by its potential to interact with enzymes and receptors, making it a valuable compound in medicinal chemistry.

Is N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8) safe?

Safety of N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8) depends on its application and exposure conditions. It is generally considered toxic if ingested or inhaled, so proper handling and protective measures are essential. Safety standards recommend using it in controlled environments with appropriate personal protective equipment (PPE) to minimize risks.

How should N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8) be stored?

N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide (CAS: 302962-49-8) should be stored in a cool, dry, and dark place, away from moisture and direct sunlight. It is best kept in a sealed container at a temperature below 25°C to maintain stability. Proper storage conditions are crucial to prevent degradation and ensure the compound remains effective for research or industrial use.

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