Thiazolyl Blue

Basic Information

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CAS Number

298-93-1

Molecular Formula

C18H16BrN5S

Molecular Weight

414.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

195 °C (dec.)

Boiling Point

°Cat760mmHg

Solubility

methanol: 5 mg/mL, clear

SMILES

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CC1=C(SC(=N1)[N+]2=NC(=NN2C3=CC=CC=C3)C4=CC=CC=C4)C.[Br-]

InChI

InChI=1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1

InChIKey

AZKSAVLVSZKNRD-UHFFFAOYSA-M

LogP

log Kow = -2.32 /Estimated/

Complexity

410

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H341 Suspected of causing genetic defects
Germ cell mutagenicity

Sensitiveness

Light Sensitive

Synonyms & References

English

UNII-EUY85H477I
NSC-367079
2H-Tetrazolium,5-dimethyl-2-thiazolyl)-2,5-diphenyl-, bromide
3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide
EUY85H477I
SCHEMBL8812
DTXSID60889338
SY036876
NSC-60102
FT-0631910
Methylthiazolyldiphenyl-tetrazolium bromideMTT
2H-Tetrazolium,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide
Thiazolyl Blue;Thiazolyl Blue Tetrazolium Bromide;Methylthiazolyldiphenyl-tetrazolium bromide
3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide
s10382
Thiazolyl Blue Tetrazolium Bromide, Vetec(TM) reagent grade, 98%
Methylthialazole Tetrazolium
NSC367079
MTT;Thiazolyl Blue Tetrazolium (bromide);Methylthiazolyldiphenyl-tetrazolium (bromide)
T-3450
Q27124034
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium Bromide
MTT
M3297
D0801
2H-Tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1:1)
2-(4,5-Dimethyl-2-thiazolyl)-3,5-diphenyl-2H-tetrazol-3-ium Bromide
THIAZOLYL BLUE [HSDB]
Thiazolyl blue tetrazolium bromide
NSC 367079
HY-15924

MDL Number

MFCD00011964

Customs Code

29341000

FAQ

What is Thiazolyl Blue (CAS: 298-93-1)?

Thiazolyl Blue, also known as MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), is a yellowish solid with the chemical formula C12H17N3O6S. It is widely used in biochemical assays for detecting cell viability and metabolic activity. Its key characteristic is the ability to be reduced by living cells to a blue formazan product, making it an essential reagent in research and pharmaceutical applications.

What are the main uses of Thiazolyl Blue (CAS: 298-93-1)?

Thiazolyl Blue (CAS: 298-93-1) is primarily used in pharmaceutical research for drug development and toxicity testing. It serves as a vital component in cell viability assays, such as the MTT assay, to measure metabolic activity in cultured cells. Additionally, it finds applications in industrial dye production and as a colorant in food, though its primary role remains in scientific and medical research.

Is Thiazolyl Blue (CAS: 298-93-1) safe?

Thiazolyl Blue (CAS: 298-93-1) is generally considered safe when used in recommended concentrations and under proper handling conditions. However, it may cause mild irritation if inhaled or contacted with skin. Safety guidelines recommend using gloves, safety goggles, and adequate ventilation. It is not classified as a hazardous substance under major regulations but should be handled with care as per standard laboratory safety protocols.

How should Thiazolyl Blue (CAS: 298-93-1) be stored?

Thiazolyl Blue (CAS: 298-93-1) should be stored in a cool, dry place, preferably refrigerated at 2-8°C, in airtight containers to prevent moisture exposure. Protection from light is essential to maintain its stability and prevent degradation. Avoid storing near incompatible chemicals, and ensure the container is sealed to preserve potency and safety for extended use.