(2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (non-preferred name) | CAS No. 294855-91-7

(2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (non-preferred name)

Basic Information

CAS Number

294855-91-7

Molecular Formula

C25H42N2O7

Molecular Weight

482.62 g/mol

AD

Basic Physical Properties

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)ON1C(=O)CCC1=O)C(O)=O

InChI

InChI=1S/C25H42N2O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(28)26-20(25(32)33)16-19-24(31)34-27-22(29)17-18-23(27)30/h20H,2-19H2,1H3,(H,26,28)(H,32,33)/t20-/m0/s1

InChIKey

KLBZDGJNRTVIAJ-FQEVSTJZSA-N

LogP

4.424500000000002

Topological Polar Surface Area

130.08 Ų

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

650

Synonyms & References

English

  • Liraglutide Int.
  • (S)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxo-2-palmitamidopentanoic acid
  • Pal-Glu(OSu)-OH
  • AMY4567
  • ZB0999
  • L-Glutamic acid, N-(1-oxohexadecyl)-, 5-(2,5-dioxo-1-pyrrolidinyl) ester

MDL Number

MFCD32695506

FAQ

What are the physical and chemical properties of (2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (CAS: 294855-91-7)?

The compound is a white to off-white crystalline solid with a molecular weight of approximately 530.64 g/mol. It is poorly soluble in water but soluble in organic solvents like DMSO. The compound exhibits good stability under normal conditions but is sensitive to strong bases and reducing agents. It is reactive towards nucleophiles and can undergo hydrolysis under basic conditions.

How is (2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (CAS: 294855-91-7) typically synthesized?

The compound is synthesized through a multi-step process involving the formation of a pyrrolidone intermediate followed by alkylation and amidation reactions. Commonly, the intermediate is treated with a palmitoyl chloride in the presence of a base such as triethylamine. The reaction conditions and catalysts used can vary, but the goal is to achieve a high yield and good selectivity towards the desired product.

What industries use (2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (CAS: 294855-91-7)?

This compound is primarily used in the pharmaceutical industry for the development of novel drug candidates. It may also find applications in the polymer industry as a modification reagent to improve material properties. Additionally, it could be utilized in sensor technologies for specific chemical detection due to its functional groups.

What precautions should be taken when handling (2S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-2-(palmitoylamino)pentanoic acid (CAS: 294855-91-7)?

When handling this compound, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a sealed container in a cool, dry place away from direct sunlight and strong acids or bases. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed instructions on handling and disposal.

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