Tetrahydropalmatine

Basic Information

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CAS Number

2934-97-6

Molecular Formula

C21H25NO4

Molecular Weight

355.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Powder

Melting Point

148.0 to 152.0 deg-C

Boiling Point

482.9°C at 760 mmHg

Density

1.2300

Flash Point

138.7°C

Solubility

Methanol,DMSO,Acetontrile

Refractive Index

1.608

Specific Rotation

-291° (c=0.8, in 95% alcohol)

SMILES

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COC1=C(OC)C(C2)=C(C=C1)CC3N2CCC4=C3C=C(OC)C(OC)=C4

InChI

InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3

InChIKey

AEQDJSLRWYMAQI-UHFFFAOYSA-N

LogP

3.376500000000002

Topological Polar Surface Area

40.160000000000004 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

475

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

Tetrahydropalmatin
tetrahydropalmatine
rotundine
5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-6h-dibenzo[a,g] quinolizine
DL-Tetrahydropalmatine
Rotundinum
2,3-methylenedioxy-9,10-dimethoxytetrahydroprotoberberine
Berberine,tetrahydro
Canadin
Canadine dl-form
dl-Canadine
tetrahydropulmatine
2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline
THP
5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine
(+/-)-Tetrahydropalmatine
Tetrahydropalmatine hydrochloride
(+-)-Corydalis B
Spectrum_001554
SpecPlus_000956
Spectrum5_000578
Spectrum4_0017
Tetrahydropalmatine
(+/-)-Tetrahydropalmatine,dl-Tetrahydropalmatine,(R,S)-Tetrahydropalmatine,(+/-)-Corydalis B

MDL Number

MFCD00214191

FAQ

What are the physical and chemical properties of Tetrahydropalmatine (CAS: 2934-97-6)?

Tetrahydropalmatine (CAS: 2934-97-6) is a crystalline compound with a molecular weight of approximately 244.25 g/mol. It has a solubility of about 1 mg/mL in water and is slightly soluble in methanol. Chemically, it is less reactive with common reagents but can undergo ring-opening reactions under certain conditions.

How is Tetrahydropalmatine (CAS: 2934-97-6) typically synthesized?

Tetrahydropalmatine (CAS: 2934-97-6) is synthesized through a series of steps including condensation and ring-opening reactions. Common methods involve the use of catalytic hydrogenation and selective oxidation. The overall yield can range from 50-70%, with high selectivity towards the desired product.

What industries use Tetrahydropalmatine (CAS: 2934-97-6)?

Tetrahydropalmatine (CAS: 2934-97-6) is primarily used in the pharmaceutical industry for its potential as an anti-inflammatory and analgesic agent. It also has applications in the food industry as a flavor enhancer and in the cosmetic sector as a skin-care ingredient.

What precautions should be taken when handling Tetrahydropalmatine (CAS: 2934-97-6)?

When handling Tetrahydropalmatine (CAS: 2934-97-6), wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store in a cool, dry place away from direct sunlight. Use a fume hood during handling and disposal, and follow standard laboratory safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.