2-(Trimethylsilyl)ethanol

Basic Information

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CAS Number

2916-68-9

Molecular Formula

C5H14OSi

Molecular Weight

118.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

Boiling Point

75°C/41mmHg

Refractive Index

n20/D 1.423(lit.)

SMILES

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C[Si](C)(C)CCO

InChI

InChI=1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3

InChIKey

ZNGINKJHQQQORD-UHFFFAOYSA-N

LogP

1.3169

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

46.5

Safety Information

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GHS Hazard Pictograms

H226

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

Hazard Class

Class 3 Class 3

Synonyms & References

English

CS-0015144
UNII-GF24TDM0VO
Trimethyl-2-hydroxyethylsilane
3,5-Dimethyl-4-isoxazolemethanol
EINECS 220-844-5
2-trimethylsilyl ethanol
SCHEMBL151
s19375
PB47630
STR05012
2-HYDROXYETHYLTRIMETHYLSILANE
TMSCH2CH2OH
J-506688
143591-29-1
2-(Trimethylsilyl) ethanol
J-802043
A25418
2916-68-9
DTXSID80183421
.BETA.-(TRIMETHYLSILYL)ETHANOL
2-trimethylsilylethanol
AMY28668
MFCD00002825
WLN: Q2-SI-1&1&1
T1441
GF24TDM0VO
2-(Trimethylsilyl)ethanol, 99%
2-(trimethylsilyl)ethan-1-ol
2-(trimethylsilyl)ethyl alcohol
Silane, (2-hydroxyethyl)trimethyl-
2-(trimethylsilyl)-ethanol

MDL Number

MFCD00002825

Customs Code

29310095

FAQ

What is 2-(Trimethylsilyl)ethanol (CAS: 2916-68-9)?

2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) is a colorless, volatile liquid with the chemical formula C5H14OSi. It is a silyl ether derivative of ethanol, characterized by its low polarity and stability in organic synthesis. This compound is commonly used as a protecting group in pharmaceutical and chemical research due to its ability to shield hydroxyl groups during reactions.

What are the main uses of 2-(Trimethylsilyl)ethanol (CAS: 2916-68-9)?

2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) is primarily utilized in pharmaceuticals for protecting hydroxyl groups during complex molecule synthesis. It also serves as a derivatizing agent in analytical chemistry, aiding in chromatographic analysis. Industrial applications include use as a reagent in silicone compound production, while its stability makes it valuable in research for solvent and intermediate purposes.

Is 2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) safe?

2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) is generally considered safe when handled properly, with low toxicity. However, it may cause mild skin or eye irritation. Safety guidelines recommend using in a well-ventilated area, wearing gloves and safety goggles, and following standard chemical handling protocols. It is not classified as hazardous under OSHA or DOT regulations but should be treated with care.

How should 2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) be stored?

2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) should be stored in a sealed, airtight container at 2-8°C in a cool, dry place away from light. It is stable under normal conditions but requires protection from moisture and air to prevent degradation. Keep in a well-ventilated storage area to ensure safety and prolong shelf life.