Canertinib dihydrochloride

Basic Information

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CAS Number

289499-45-2

Molecular Formula

C24H27Cl3FN5O3

Molecular Weight

558.87 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

691°C at 760 mmHg

Density

1.355

Flash Point

371.7°C

Solubility

DMSO: >10mg/mL

Refractive Index

1.649

SMILES

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C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl

InChI

InChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H

InChIKey

JZZFDCXSFTVOJY-UHFFFAOYSA-N

LogP

5.235100000000004

Topological Polar Surface Area

88.61000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

671

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

D03350
S0711
Q-101362
CI-1033
CHEMBL545315
Canertinib dihydrochloride salt
Canertinib HCl
PD183805
BCP01902
2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-, dihydrochloride
PD-0183805
PD 183805
289499-45-2
UNII-ICJ93X8X90
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride
N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;dihydrochloride
PD-183805 dihydrochloride
2-Propenamide, N-(4-((3-chloro-4-fluorophenyl) amino)-7-(3-(4-morpholinyl) propoxy)-6-quinazolinyl)-, dihydrochloride
N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide dihydrochloride
Canertinib dihydrochloride (USAN)
HY-10367A
CI-1033 dihydrochloride;PD-183805 dihydrochloride
FT-0724289
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
SCHEMBL2052123
Canertinib dihydrochloride [USAN]
N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-(3-(4-MORPHOLINYL)PROPOXY)-6-QUINAZOLINYL)-2-PROPENAMIDE DIHYDROCHLORIDE
A19399
ICJ93X8X90
CANERTINIB DIHYDROCHLORIDE [WHO-DD]
CANERTINIB DIHYDROCHLORIDE [MI]

MDL Number

MFCD09954112

FAQ

What is Canertinib dihydrochloride (CAS: 289499-45-2)?

Canertinib dihydrochloride is a chemotherapy agent with the chemical formula C21H16N4O2⋅2HCl. It is characterized by its potent antitumor activity, particularly against certain types of cancer cells.

What are the main uses of Canertinib dihydrochloride (CAS: 289499-45-2)?

Canertinib dihydrochloride is primarily used in the treatment of non-small cell lung cancer and other solid tumors. It is administered orally and is part of the therapeutic regimen for advanced or metastatic cancers.

Is Canertinib dihydrochloride (CAS: 289499-45-2) safe?

Canertinib dihydrochloride can be safe when used under the guidance of a healthcare professional. However, it is important to follow all safety precautions, including monitoring for side effects such as nausea, vomiting, and skin changes. Protective measures include avoiding contact with eyes and skin, and proper disposal of unused medication.

How should Canertinib dihydrochloride (CAS: 289499-45-2) be stored?

Canertinib dihydrochloride should be stored in a tightly closed container at room temperature (15-30°C) away from direct sunlight and moisture. It is crucial to keep it out of reach of children and pets and follow local regulations for the disposal of unused medication and packaging.