(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid | CAS No. 28416-82-2

(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

Basic Information

CAS Number

28416-82-2

Molecular Formula

C21H26F2O5

Molecular Weight

396.43 g/mol

AD

Basic Physical Properties

Melting Point

303-305°C

Boiling Point

568.44°C at 760 mmHg

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)O)O)C)O)F)C)F

InChI

InChI=1S/C21H26F2O5/c1-10-6-12-13-8-15(22)14-7-11(24)4-5-18(14,2)20(13,23)16(25)9-19(12,3)21(10,28)17(26)27/h4-5,7,10,12-13,15-16,25,28H,6,8-9H2,1-3H3,(H,26,27)/t10-,12+,13+,15+,16+,18+,19+,20+,21+/m1/s1

InChIKey

QSVBUQTYFQFEHC-IDIDPBNYSA-N

LogP

2.3669000000000002

Topological Polar Surface Area

94.83000000000001 Ų

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

824

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

  • Discontinued see F599490
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • UNII-EUS9FD6209
  • AS-74788
  • AC-1685
  • A12383
  • J-017063
  • AKOS025401447
  • Fluticasone 17?-Carboxylic Acid
  • Flumethasone Acid
  • 6alpha, 9alpha-Difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylic acid
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
  • (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • 6alpha,9alpha-Difluoro-11beta,17alpha-dihydroxy-16alpha-methylpregna- 3-oxo-1,4-diene-17beta-carboxylic Acid
  • AMY38258
  • NS00028482
  • (1R,2R,3aS,3bS,5S,9aS,9bR,10S,11aS)-5,9b-difluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1-carboxylic acid
  • Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
  • Fluticasone 17 beta -Carboxylic Acid
  • DTXSID10431346
  • 28416-82-2
  • Fluticasone 17beta-Carboxylic Acid
  • 6?,9?-Difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carboxylic Acid
  • Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6alpha,11beta,16alpha,17alpha)-
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID, 6,9-DIFLUORO-11,17-DIHYDROXY-16-METHYL-3-OXO-, (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-
  • 6?,9?-Difluoro-11?-,17?-dihydroxy-3-oxoandrosta-1,4-diene-17?-carboxylic Acid
  • EUS9FD6209
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • SCHEMBL1625921
  • 6alpha,9alpha-Difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylic Acid
  • (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid

MDL Number

MFCD09832931

FAQ

What regulatory guidelines apply to (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (CAS: 28416-82-2)?

This compound falls under the scope of various regulatory guidelines such as the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), REACH regulations, FDA requirements for pharmaceuticals, and EPA regulations for environmental safety. Specific handling, storage, and disposal guidelines must be adhered to based on its hazardous properties.

Are there alternatives to (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (CAS: 28416-82-2) in synthesis?

Several alternatives can be used in the synthesis of this compound, including different reagents such as 17α-ethynylestradiol and analogs like 17α-methyltestosterone. These alternatives can provide similar functional groups with varying properties for different synthetic routes.

What is the market or research trend for (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (CAS: 28416-82-2)?

Market trends for this compound indicate growing interest in its potential use in pharmaceuticals and research. Research is focusing on its hormonal activity and potential applications in hormone therapy. The compound is also being studied for its pharmacological properties in alternative medicine.

How should waste containing (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (CAS: 28416-82-2) be handled?

Waste containing this compound should be managed according to environmental protection regulations. Proper waste collection, storage, and disposal should be implemented. Incineration or professional waste disposal services are recommended to ensure the safe and environmentally friendly handling of the waste.

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