D-Dithiothreitol

Basic Information

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CAS Number

27565-41-9

Molecular Formula

C4H10O2S2

Molecular Weight

154.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

42-44 ºC

Boiling Point

125-130 °C (2 mmHg)

Flash Point

>230 °F

Solubility

H2O: 50 mg/mL, clear, colorless

Refractive Index

1.5200 (estimate)

SMILES

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SC[C@H]([C@@H](CS)O)O C4H10O2S2

InChI

InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1

InChIKey

VHJLVAABSRFDPM-QWWZWVQMSA-N

LogP

-0.43220000000000003

Topological Polar Surface Area

40.46 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

Synonyms & References

English

DL-Dithiothreitol
DTT
Clelands REDUCTACRYL
threo-1,4-Dimercapto-2,3-butanediol
1,4-dithio-dl-threitol sol.
1,4-Dithio-DL-threitol
dithiothreitol (dtt) sequencing grade
dithiothreitol molecular biology*reagent
DithiothreitollelandsReagenz
Dithithreitol
Clelands
1,4-Dithioerythritol
1,4-Dithiothreitol
DL-Dithothreitol
Dithiothreitol
Dithiothreitol Solution
DL-1,4-Dithiothreitol
Clelands Reagent
(+/-)-1,4-Dithio-D-threitol
DL-Threo-1,4-dimercapto-2,3-butanediol
Cleland's reagent
(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL
D-1,4-Dithiothreitol
D-Dtt
1,4-Dithiothreithol
(2S,3S)-1,4-disulfanylbutane-2,3-diol
(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
Sputolysin
D-threo-1,4-Dimercapto-2,3-butanediol
L-Dithiothreitol
L-1,4-Dithiothreitol

MDL Number

MFCD00004877

Customs Code

2930909090

FAQ

What regulatory guidelines apply to D-Dithiothreitol (CAS: 27565-41-9)?

D-Dithiothreitol (CAS: 27565-41-9) falls under the GHS classification as a skin and eye irritant. It is subject to the REACH regulations in the European Union, requiring manufacturers and importers to register substances above a certain tonnage. FDA and EPA have specific requirements for the safe handling and disposal of this compound, including reporting and recording of usage and disposal methods.

Are there alternatives to D-Dithiothreitol (CAS: 27565-41-9) in synthesis?

Alternative reducing agents such as tris(2-carboxyethyl)phosphine (TCEP) and sodium borohydride are often used as alternatives to D-Dithiothreitol (CAS: 27565-41-9) in various synthetic processes, especially in thiol-disulfide exchange reactions. These alternatives offer similar reductive properties but may have different handling and environmental considerations.

What is the market or research trend for D-Dithiothreitol (CAS: 27565-41-9)?

The market for D-Dithiothreitol (CAS: 27565-41-9) is growing due to its applications in proteomics and biotechnology. Research trends are focusing on its use in protein thiol analysis and modification, driving demand in academic and industrial settings. However, there is also interest in developing more environmentally friendly alternatives to reduce environmental impact.

How should waste containing D-Dithiothreitol (CAS: 27565-41-9) be handled?

Waste containing D-Dithiothreitol (CAS: 27565-41-9) should be collected in appropriate containers, labeled with the contents, and stored in a secure area. It should be neutralized and treated with a suitable oxidizing agent to minimize environmental impact before disposal. Professional waste disposal services are recommended to ensure compliance with environmental regulations and safe disposal.