Imidazo[1,2-a]pyridine

Basic Information

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CAS Number

274-76-0

Molecular Formula

C7H6N2

Molecular Weight

118.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

103 °C/1 mmHg

Refractive Index

n20/D 1.626(lit.)

SMILES

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C1=CC2=NC=CN2C=C1

InChI

InChI=1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H

InChIKey

UTCSSFWDNNEEBH-UHFFFAOYSA-N

LogP

1.3342999999999998

Topological Polar Surface Area

17.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

103

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

imidazolo[1,2-a]pyridine
AM86817
4H-imidazo[1,2-a]pyridine
274-76-0
AC-23329
Imidazo[1,2-a]pyridine
BP-13302
I0922
1H-imidazo[1,2-a]pyridine
J-521496
imidazo [1,2-a] pyridine
UTCSSFWDNNEEBH-UHFFFAOYSA-N
J-016780
Imidazo[1
CS-W016589
imidazo[1,2-a]-pyridine
SCHEMBL7883
SY024154
EN300-55659
DTXSID80181821
MFCD00005553
A819085
Imidazo(1,2-a)pyridine
BDBM50269837
AS-17415
Imidazo[1,2-a]pyridine, 99%
imidazo[l,2-a]pyridine
H-imidazo[1,2-a]pyridine
Z838912682
FT-0631896
AKOS005144331

MDL Number

MFCD00005553

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Imidazo[1,2-a]pyridine (CAS: 274-76-0)?

Imidazo[1,2-a]pyridine is a crystalline solid with a molecular weight of approximately 121.13 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophilic substitution reactions. It has a high stability under normal conditions but can undergo thermal degradation at higher temperatures.

How is Imidazo[1,2-a]pyridine (CAS: 274-76-0) typically synthesized?

Imidazo[1,2-a]pyridine can be synthesized via the condensation of 1H-pyrazole and 2-aminopyridine using an acid catalyst. The reaction typically proceeds with high selectivity and yields up to 85%. Common solvents used include acetic acid or trifluoroacetic acid.

What industries use Imidazo[1,2-a]pyridine (CAS: 274-76-0)?

Imidazo[1,2-a]pyridine finds applications in the pharmaceutical industry for the development of anti-inflammatory and antitumor agents. It is also used in the manufacturing of organic electronic devices, particularly in semiconductors and sensors due to its unique electronic properties.

What precautions should be taken when handling Imidazo[1,2-a]pyridine (CAS: 274-76-0)?

When handling Imidazo[1,2-a]pyridine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.