Cefazolin sodium

Basic Information

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CAS Number

27164-46-1

Molecular Formula

C14H13N8NaO4S3

Molecular Weight

476.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

190°C

Boiling Point

No data available

Flash Point

No data available

Solubility

H2O: 50 mg/mL, clear, colorless

Refractive Index

20 ° (C=10, H2O)

Vapor Pressure

No data available

SMILES

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CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]

InChI

InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

InChIKey

FLKYBGKDCCEQQM-WYUVZMMLSA-M

LogP

-1.64200

Complexity

746

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents.

Sensitiveness

Light Sensitive

Toxicity

LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead)

Synonyms & References

English

Sodium (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
Cefazolin sodium 100 microg/mL in Acetonitrile/Water
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-,(6R,7R)-,sodium
CEFAZOLIN SODIUM
EN300-6731106
BDBM50247885
Q27106104
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-, (6R-trans)-, sodium salt
CEFAZOLIN SODIUM [JAN]
sodium 7beta-(1H-tetrazol-1-yl)acetamido-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate
Cephazolin Sodium
HMS1920K07
AC-13166
Liviclina
Monosodium (6R,7R)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, sodium salt, (6R,7R)- (1:1)
Sodium cefazolin
DTXCID001473947
Cefamedin
EU-0100274
CEFAZOLIN SODIUM (USP MONOGRAPH)
Sodium (6R,7R)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
EINECS 248-278-4
AS-12230
Cefazolin sodium salt, 89.1-110.1%
s4595
ANCEF IN PLASTIC CONTAINER
NCGC00093731-01
CEZ sodium
DTXSID901015786
sodium (6R,7R)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-((5-methyl-1,3,4-thiadiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

MDL Number

MFCD00056883

Customs Code

2941905300

FAQ

What is Cefazolin sodium (CAS: 27164-46-1)?

Cefazolin sodium is a first-generation cephalosporin antibiotic used to treat bacterial infections. Its chemical formula is C16H17N5O4S2Na, and it appears as a white crystalline powder. It is soluble in water and has a broad spectrum of activity against Gram-positive and some Gram-negative bacteria. The CAS number 27164-46-1 ensures accurate identification in chemical databases and research contexts.

What are the main uses of Cefazolin sodium (CAS: 27164-46-1)?

Cefazolin sodium is primarily used in pharmaceuticals to combat bacterial infections such as skin, respiratory, and urinary tract infections. It is also applied in veterinary medicine and research for antimicrobial studies. The CAS number 27164-46-1 is critical for ensuring proper application in clinical settings and industrial production.

Is Cefazolin sodium (CAS: 27164-46-1) safe?

Cefazolin sodium is generally safe when used as directed, but it may cause allergic reactions or gastrointestinal side effects. Safety standards require proper handling, storage, and disposal to prevent contamination. The CAS number 27164-46-1 ensures traceability and adherence to regulatory guidelines for safe use.

How should Cefazolin sodium (CAS: 27164-46-1) be stored?

Cefazolin sodium should be stored in a cool, dry place (20-25°C), away from light and moisture. It requires airtight containers to maintain stability and prevent degradation. The CAS number 27164-46-1 ensures correct storage conditions for preserving its efficacy and safety.