1H-Pyrrolo[2,3-b]pyridine

Basic Information

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CAS Number

271-63-6

Molecular Formula

C7H6N2

Molecular Weight

118.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

104.0 to 107.0 deg-C

Boiling Point

270°C

Flash Point

270℃

Refractive Index

1.5500 (estimate)

SMILES

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C1=CC2=C(NC=C2)N=C1

InChI

InChI=1S/C7H6N2/c1-2-6-3-5-9-7(6)8-4-1/h1-5H,(H,8,9)

InChIKey

MVXVYAKCVDQRLW-UHFFFAOYSA-N

LogP

1.5628999999999997

Topological Polar Surface Area

28.68 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

103

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

STR01850
NSC 67063
SC1771
pyrrolo[2,3-b]pyridine
NSC-77951
7-Aza-1-pyrindine
1H-pyrrolo(2,3-b)-pyridine
CHEMBL389685
1,7-Diazaindene
7H-Pyrrolo(2,3-b)pyridine
CHEBI:194830
1,7-Dideazapurine
271-63-6
PB32078
F0001-0881
NSC67063
7-Azaindole
NCIOpen2_000707
1-H-pyrrolo[2,3-b]pyridine
7H-Pyrrolo[2,3-b]pyridine
7-Azaindole, 98%
pyrrolo[2,3-b]-pyridine
A-9500
1H-PYRROLO(2,3-b)PYRIDINE
PS-4533
EN300-25796
QX4465NR9T
HY-50542
BCP26852
CS-B0516
NSC77951

MDL Number

MFCD00005606

Customs Code

2933990090

FAQ

What is 1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6)?

1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) is a heterocyclic organic compound with the chemical formula C5H5N2. It features a fused ring structure combining a pyrrole and pyridine ring, making it a key intermediate in pharmaceutical and chemical synthesis. This compound is known for its aromaticity and potential applications in drug development. Its physical properties include a colorless solid appearance and limited solubility in water, though it dissolves in polar organic solvents. The molecule is widely studied for its biological activity and structural versatility in chemical research.

What are the main uses of 1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6)?

1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) is primarily used in pharmaceutical research as a building block for developing drugs, including antipsychotics and antihistamines. It also serves as a precursor in organic synthesis for creating complex molecules and functional materials. In industrial applications, it may be utilized in the production of dyes, agrochemicals, and specialty chemicals. Its unique structure makes it valuable in chemical research for exploring new reactivity patterns and biological properties. The compound's versatility supports its role in various scientific and commercial fields.

Is 1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) safe?

1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) requires careful handling due to its potential toxicity. Inhalation or skin contact may cause irritation, and it should be treated as a hazardous chemical under appropriate safety standards. Protective measures include wearing gloves, safety goggles, and a lab coat, and working in a well-ventilated area. Safety data sheets (SDS) recommend avoiding prolonged exposure and following OSHA guidelines for chemical storage and disposal. While not classified as a carcinogen, it should be handled with caution to minimize health risks.

How should 1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) be stored?

1H-Pyrrolo[2,3-b]pyridine (CAS: 271-63-6) should be stored in a sealed, airtight container made of inert material such as glass or polyethylene. It is best kept in a cool, dry place at 2-8°C to maintain stability and prevent degradation. Avoid exposure to moisture, light, and air to ensure long-term preservation. Storage conditions should also comply with chemical safety standards, including proper labeling and segregation from incompatible substances. Keep away from heat sources and ensure proper ventilation in storage areas.