5(6)-FITC | CAS No. 27072-45-3

5(6)-FITC

Basic Information

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CAS Number

27072-45-3

Molecular Formula

C42H22N2O10S2

Molecular Weight

389.39 g/mol

EINECS

248-207-7

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

>360 °C

Boiling Point

708.6±60.0 °C at 760 mmHg

Density

1.5400

Flash Point

382.4±32.9 °C

Refractive Index

1.753

SMILES

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OC1=CC=C2C(OC3=CC(O)=CC=C3C22OC(=O)C3=CC(=CC=C23)N=C=S)=C1

InChI

InChI=1S/C21H11NO5S/c23-12-2-5-16-18(8-12)26-19-9-13(24)3-6-17(19)21(16)15-4-1-11(22-10-28)7-14(15)20(25)27-21/h1-9,23-24H

InChIKey

MHMNJMPURVTYEJ-UHFFFAOYSA-N

LogP

4.400100000000002

Topological Polar Surface Area

88.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

668

Safety Information

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GHS Hazard Pictograms

H334

Hazard Statement

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Stability

humidity sensitive

Sensitiveness

thermally sensitive

Synonyms & References

English

FluoresceinIsothiocyanate,Isomers1&11
Spiroisobenzofuran-1(3H),9-9Hxanthen-3-one, 3,6-dihydroxy-5(or 6)-isothiocyanato-
Fluorescein 5(6)-isothiocyanate,FITC, Fluorescein isothiocyanate
Fluorescein5(6)-isot
5(6)-FITC
Fluorescein 5(6)-isothiocyanat, mixture of isomers >90%
Fluorescein Isothiocyanate (Mixture of 5- and 6- isoMers)
Isothiocyanatofluorescein
fluorescein isothiocyanate
Fluorescein isothiocyanate FITC
5(6)-fluorescein isothiocyanate
SPECTRACOMP(TM) FITC PARTICLES
2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-ISOTHIOCYANATO-BENZOIC ACID
3',6'-Dihydroxy-5(or 6)-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
5-FLUORESCEIN ISOTHIOCYANATE
5-FLUORESCEIN ISOTHIOCYANATE, ISOMER I
5-FLUORESCEIN ISOTHIOCYANATEISOMER
FLUORESCEIN-5-ISOTHIOCYANATE ISOMER I
FLUORESCEIN 5-ISOTHIOCYANATE, ISOMER 1
Fluorescein5(6)-isothiocyanate
Fluorescein Isothiocyanate (mixture of 5- and 6- isomers)
FLUORESCEIN-ISO-THIOCYANATE
5-FITC
5-Isothionatofluorescein
FITC
FITC ISOMER
FITC isomer I
FITC 'ISOMER I'
FITC,5-lsothiocyanato fluorescein
FITC-CELITE(R)
FITC-I

MDL Number

MFCD00005063

EC Number

248-207-7

Customs Code

29321900

FAQ

What regulatory guidelines apply to 5(6)-FITC (CAS: 27072-45-3)?

5(6)-FITC (CAS: 27072-45-3) is regulated under the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals. It falls under the categories of flammable liquids and requires appropriate hazard communication labels. In the European Union, it is classified under REACH regulations, and in the U.S., it is regulated by the FDA and EPA for safe handling and disposal. Additionally, local and regional regulations may apply depending on the country and usage scenario.

Are there alternatives to 5(6)-FITC (CAS: 27072-45-3) in synthesis?

There are several alternatives to 5(6)-FITC in synthesis, such as Alexa Fluor dyes and Cy dyes, which offer similar functionalities with varying spectra. Other substitutes include rhodamine derivatives and other fluorescent probes. These alternatives can be chosen based on specific experimental requirements such as wavelength, photostability, and compatibility with other reagents.

What is the market or research trend for 5(6)-FITC (CAS: 27072-45-3)?

The market for 5(6)-FITC (CAS: 27072-45-3) is driven by its extensive use in biological research, particularly in fluorescence microscopy and flow cytometry. Current research trends focus on developing more stable and brighter fluorophores, as well as exploring new labeling techniques and applications. The demand for 5(6)-FITC is expected to remain stable due to its well-established role in the field, although there is ongoing exploration of more advanced alternatives.

How should waste containing 5(6)-FITC (CAS: 27072-45-3) be handled?

Waste containing 5(6)-FITC (CAS: 27072-45-3) should be collected in appropriate containers and stored separately to prevent contamination. Proper disposal involves incineration or professional waste disposal services that comply with local regulations. Precautions include ensuring that waste does not come into contact with skin or eyes, and following all safety guidelines to minimize environmental impact. Disposal methods should be conducted by trained personnel with the necessary protective equipment and documentation.