5-methyl-2-phenylpyridine

Basic Information

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CAS Number

27012-22-2

Molecular Formula

C12H11N

Molecular Weight

169.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

53.0 to 57.0 deg-C

Boiling Point

166°C/16mmHg

SMILES

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CC1=CN=C(C=C1)C2=CC=CC=C2

InChI

InChI=1S/C12H11N/c1-10-7-8-12(13-9-10)11-5-3-2-4-6-11/h2-9H,1H3

InChIKey

ZYLPQYYLLRBVOK-UHFFFAOYSA-N

LogP

3.0570200000000014

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

149

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

ZYLPQYYLLRBVOK-UHFFFAOYSA-N
Pyridine, 5-methyl-2-phenyl-
EINECS 248-163-9
FT-0692777
AKOS006292124
CBA01222
6-phenyl-3-picoline
3-methyl-6-phenylpyridine
DS-7491
64828-54-2
2-phenyl-5-methylpyridine
M2969
SCHEMBL404433
27012-22-2
C74402
SY100654
NS00050016
5-methyl-2-(phenyl)pyridine
DTXSID00949783
2-phenyl-5-methyl pyridine
CS-0085797
A877050
MFCD04114180
5-Methyl-2-phenylpyridine
5-METHYL-2-PHENYL-PYRIDINE
Pyridine,5-methyl-2-phenyl-
2-PHENYL-5-METHYLPYRIDINE
5-Methyl-2-phenyl-pyridin
Einecs 248-163-9
FCH848852
VP14812

MDL Number

MFCD04114180

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-methyl-2-phenylpyridine (CAS: 27012-22-2)?

5-Methyl-2-phenylpyridine (CAS: 27012-22-2) is a solid with a crystalline form. Its molecular weight is approximately 175.23 g/mol. It is slightly soluble in water but soluble in common organic solvents such as ethanol and acetone. This compound exhibits moderate reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be handled with care to prevent degradation.

How is 5-methyl-2-phenylpyridine (CAS: 27012-22-2) typically synthesized?

5-Methyl-2-phenylpyridine (CAS: 27012-22-2) is commonly synthesized via a Friedel-Crafts acylation of 2-phenylpyridine with methanol. The reaction is conducted in the presence of a Lewis acid catalyst like aluminum chloride. High selectivity and yield are achieved under these conditions, making this a widely used method in organic synthesis.

What industries use 5-methyl-2-phenylpyridine (CAS: 27012-22-2)?

5-Methyl-2-phenylpyridine (CAS: 27012-22-2) is used in various industries. It is a key intermediate in pharmaceuticals, where it is used in the synthesis of certain drugs. It also finds applications in the development of sensors and semiconductors due to its unique electronic properties. Additionally, it is utilized in the production of certain polymers where its stability and reactivity are advantageous.

What precautions should be taken when handling 5-methyl-2-phenylpyridine (CAS: 27012-22-2)?

When handling 5-methyl-2-phenylpyridine (CAS: 27012-22-2), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, follow the safety data sheet (SDS) guidelines for cleanup. Dispose of any waste material according to local regulations to ensure environmental safety.