N-Ethylpyrrolidinone

Basic Information

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CAS Number

2687-91-4

Molecular Formula

C6H11NO

Molecular Weight

113.16 g/mol

Basic Physical Properties

Boiling Point

218°C

Refractive Index

n20/D 1.465(lit.)

SMILES

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O=C1N(CC)CCC1

InChI

InChI=1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3

InChIKey

ZFPGARUNNKGOBB-UHFFFAOYSA-N

LogP

0.6287

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

101

Safety Information

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GHS Hazard Pictograms

H302

H319

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class Comb liq Class Comb liq

Explosive Limit

1.3-7.7%(V)

Synonyms & References

English

1-Ethylpyrrolidin-2-one
NEP
n-ethyl-2-pyrrolidone
Ethyl pyrrolidinone
N-ethyl-pyrrolidone
1-Ethyl-2-pyrrolidone
1-Ethyl-2-pyrrolidinone
Agsol Ex 2
ethyl-2-pyrrolidone
ethyl-pyrrolidinone
N-Efhyl-2-Pyrrolidone
N-Ethyl-2-azapentanone
N-ethyl-2-pyrrolidinone
N-Ethyl-2-pyrrolidon
N-Ethyl-a-pyrrolidone
N-ethylpyrrolidinone
N-Ethylpyrrolidone
2-Pyrrolidinone, 1-ethyl-
Ethyl pyrrolidone
Pyrrolidinone, 1-ethyl-
H0229SX1CW
ZFPGARUNNKGOBB-UHFFFAOYSA-N
AK106210
DSSTox_RID_80212
DSSTox_CID_24413
DSSTox_GSID_44413
2-pyrrolidinone, 1-ethyl-;1-ethylpyrrolidin-2-one;2-pyrrolidinone, 1-ethy

MDL Number

MFCD00003199

Customs Code

2933790090

FAQ

What is N-Ethylpyrrolidinone (CAS: 2687-91-4)?

N-Ethylpyrrolidinone is a cyclic amide with the chemical formula C6H11NO. It is a colorless, clear liquid with a slightly sweet odor, known for its solubility in both water and organic solvents. This compound is widely used as a solvent and intermediate in chemical synthesis due to its stability and polarity. Its CAS number is 2687-91-4, and it is also referred to as 1-Pyrrolidinyl-2-propanone in some contexts.

What are the main uses of N-Ethylpyrrolidinone (CAS: 2687-91-4)?

N-Ethylpyrrolidinone (CAS: 2687-91-4) is primarily used in pharmaceuticals as a solvent for drug formulations and a key intermediate in synthesizing active pharmaceutical ingredients. It also serves as a solvent in the production of coatings, adhesives, and specialty chemicals. Additionally, it is employed in the food industry as a processing aid and in research for polymer synthesis and chemical derivatization.

Is N-Ethylpyrrolidinone (CAS: 2687-91-4) safe?

N-Ethylpyrrolidinone (CAS: 2687-91-4) is generally considered safe when handled properly, with low toxicity in short-term exposure. However, it may cause mild skin or eye irritation. Safety guidelines recommend using appropriate protective equipment, such as gloves and goggles, and ensuring adequate ventilation. It is classified as a safe chemical in food applications under regulatory standards but should be treated with care in industrial settings.

How should N-Ethylpyrrolidinone (CAS: 2687-91-4) be stored?

N-Ethylpyrrolidinone (CAS: 2687-91-4) should be stored in a cool, dry place, preferably at 25°C or below, to maintain stability. It is hygroscopic, so storage in a sealed container with controlled humidity is essential. Protection from light is recommended, and it should be kept away from incompatible materials. Proper labeling and storage in a well-ventilated area are also critical for safety.