Homoharringtonine

Basic Information

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CAS Number

26833-87-4

Molecular Formula

C29H39NO9

Molecular Weight

545.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

144-146 C

Boiling Point

713.1℃/760mmHg

Flash Point

385.1±32.9 °C

Solubility

DMSO: soluble20mg/mL, clear

Refractive Index

1.6290 (estimate)

SMILES

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CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O

InChI

InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

InChIKey

HYFHYPWGAURHIV-JFIAXGOJSA-N

LogP

2.5807

Topological Polar Surface Area

123.99000000000002 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

968

Safety Information

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GHS Hazard Pictograms

H300

H310

H330

Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral

H310 Fatal in contact with skin
Acute toxicity, dermal

H330 Fatal if inhaled
Acute toxicity, inhalation

Hazard Class

Class 6.1(a) Class 6.1(a)

Storage Conditions

2-8℃

Synonyms & References

English

MLS001424293
Omapro
NCI60_000917
BRD-K76674262-001-01-7
CHEBI:71019
Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
OMACETAXINE MEPESUCCINATE (MART.)
(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(13),4,14,19-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
Homoharringtonin
Synribo
NS00067000
D08956
CHEMBL46286
NSC 141633
BRN 5687925
CGX-635-14 (formulation)
HOMOHARRINGTONINE [MI]
NSC-758253
Tekinex
OMACETAXINE MEPESUCCINATE [INN]
HY-14944
CGX-635
AMY33459
NCGC00025155-01
SCHEMBL12745687
1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
(-)-homoharringtonine
NCGC00025155-02
6FG8041S5B
DB04865
UNII-6FG8041S5B

MDL Number

MFCD05618221

FAQ

What is Homoharringtonine (CAS: 26833-87-4)?

Homoharringtonine is a naturally occurring alkaloid derived from the plant *Cephaelis ipecacuanha*. It has the chemical formula C19H23NO4 and is known for its complex structure, which includes a quinolizidine skeleton. This compound exhibits various biological activities, including antitumor properties, and is commonly used in scientific research for its pharmacological potential.

What are the main uses of Homoharringtonine (CAS: 26833-87-4)?

Homoharringtonine is primarily used in pharmaceutical research as a potential anticancer agent due to its ability to inhibit protein synthesis. It is also studied for its applications in treating leukemia and other malignancies. In addition, it serves as a valuable compound in chemical synthesis and biological studies for its unique structural and functional properties.

Is Homoharringtonine (CAS: 26833-87-4) safe?

Homoharringtonine is not considered safe for general use and requires careful handling. It has been reported to exhibit toxicity, particularly to the liver and kidneys, when ingested or exposed in high concentrations. Safety protocols include wearing protective gear and following proper disposal procedures to minimize health and environmental risks.

How should Homoharringtonine (CAS: 26833-87-4) be stored?

Homoharringtonine should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is sensitive to moisture and light, so it should be kept in a sealed, airtight container. Proper storage conditions help maintain its stability and potency, ensuring safe handling and effective use in research or medicinal applications.