1,3-Thiazolidin-2-one

Basic Information

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CAS Number

2682-49-7

Molecular Formula

C3H5NOS

Molecular Weight

103.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

53-54 ºC

Boiling Point

247.6°C at 760 mmHg

SMILES

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O=C1SCCN1

InChI

InChI=1S/C3H5NOS/c5-3-4-1-2-6-3/h1-2H2,(H,4,5)

InChIKey

SLYRGJDSFOCAAI-UHFFFAOYSA-N

LogP

0.4427999999999999

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

73.2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Thiazolidin-2-one
1,3-Thiazolan-2-one
1,3-THIAZOLIDIN-2-ONE
2-Thiazolidinone
Tetrahydrothiazolyl thione
2-Oxothiazolidine
NSC 122613
THIAZOLIDINONE
Oxothiazolidine
M6U1ZG59XD
hydroxythiazoline
PubChem14582
SLYRGJDSFOCAAI-UHFFFAOYSA-N
NSC122613
STL140859
1,3-thiazolidin-2-one, AldrichCPR
NE26277
SY037960
AB003613

MDL Number

MFCD01332388

Customs Code

2934999090

FAQ

What is 1,3-Thiazolidin-2-one (CAS: 2682-49-7)?

1,3-Thiazolidin-2-one (CAS: 2682-49-7) is a heterocyclic organic compound with the chemical formula C3H3NSO. It features a five-membered ring containing sulfur and nitrogen atoms, and exhibits properties such as low solubility in water, moderate solubility in organic solvents, and a melting point around 140–142°C. This compound is widely recognized for its stability and reactivity in chemical synthesis.

What are the main uses of 1,3-Thiazolidin-2-one (CAS: 2682-49-7)?

1,3-Thiazolidin-2-one (CAS: 2682-49-7) is primarily used as a key intermediate in pharmaceuticals, including the synthesis of drugs like metformin. It also finds applications in industrial chemistry for producing pesticides, dyes, and additives. In research, it serves as a versatile building block for creating bioactive molecules. Additionally, it is used in food additives and as a precursor in polymer science.

Is 1,3-Thiazolidin-2-one (CAS: 2682-49-7) safe?

1,3-Thiazolidin-2-one (CAS: 2682-49-7) is generally considered safe when handled properly. However, it may cause skin and eye irritation, and inhalation of its vapors could be harmful. Safety data sheets (SDS) recommend using appropriate protective equipment, such as gloves and goggles, and ensuring adequate ventilation. It is not classified as highly toxic but should be treated with care as per OSHA and REACH guidelines.

How should 1,3-Thiazolidin-2-one (CAS: 2682-49-7) be stored?

1,3-Thiazolidin-2-one (CAS: 2682-49-7) should be stored in a cool, dry place, away from light and moisture. Keep it in a sealed, airtight container made of glass or polyethylene to maintain stability. Storage temperatures should ideally be below 25°C, and it is best to store in a well-ventilated area to prevent degradation. Avoid exposure to strong acids or bases to ensure long-term preservation.