BLU-945 | CAS No. 2660250-10-0

BLU-945

Basic Information

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CAS Number

2660250-10-0

Molecular Formula

C28H37FN6O3S

Molecular Weight

556.7 g/mol

Basic Physical Properties

SMILES

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CO[C@@H]1CCN(c2nccc(Nc3cc4c(C(C)C)ccc(N5C[C@H](CS(C)(=O)=O)[C@H]5C)c4cn3)n2)C[C@@H]1F

InChI

InChI=1S/C28H37FN6O3S/c1-17(2)20-6-7-24(35-14-19(18(35)3)16-39(5,36)37)22-13-31-27(12-21(20)22)32-26-8-10-30-28(33-26)34-11-9-25(38-4)23(29)15-34/h6-8,10,12-13,17-19,23,25H,9,11,14-16H2,1-5H3,(H,30,31,32,33)/t18-,19-,23+,25-/m1/s1

InChIKey

LIMFPAAAIVQRRD-BCGVJQADSA-N

LogP

4.324300000000004

Topological Polar Surface Area

100.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Synonyms & References

English

BLU-945
N-(2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)-5-isopropyl-8-((2R,3S)-2-methyl-3-((methylsulfonyl)methyl)azetidin-1-yl)isoquinolin-3-amine

FAQ

What is BLU-945 (CAS: 2660250-10-0)?

BLU-945 is a compound with the CAS number 2660250-10-0. It is a small molecule inhibitor of the ATR kinase, used in research to study DNA damage responses and cell cycle regulation. It has an empirical formula of C18H16N4O2 and a molecular weight of approximately 328.35 g/mol.

What are the main uses of BLU-945 (CAS: 2660250-10-0)?

BLU-945 is primarily used in research to study the effects of ATR inhibition on cellular responses to DNA damage. It is also used in the development of potential therapeutic agents for conditions associated with ATR signaling pathways.

Is BLU-945 (CAS: 2660250-10-0) safe?

BLU-945 is safe when used under proper laboratory conditions with appropriate safety measures. It is important to follow all safety guidelines and wear appropriate personal protective equipment to avoid skin contact and inhalation. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.

How should BLU-945 (CAS: 2660250-10-0) be stored?

BLU-945 should be stored in a well-ventilated, cool place away from direct sunlight and moisture. Keep it in a tightly sealed container, and avoid exposure to temperatures above 30°C. It is recommended to store it at a controlled room temperature of 15-25°C. Handle with care to prevent spillage and contamination.