N~2~-[(Benzyloxy)carbonyl]-L-glutamine

Basic Information

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CAS Number

2650-64-8

Molecular Formula

C13H16N2O5

Molecular Weight

280.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

136.0 to 140.0 deg-C

Boiling Point

604.2 ℃ at 760 mmHg

Flash Point

319.2°C

Refractive Index

1.6450 (estimate)

Specific Rotation

-7 º (c=2, EtOH)

SMILES

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C1=CC=C(C=C1)COC(=O)NC(CCC(=O)N)C(=O)O

InChI

InChI=1S/C13H16N2O5/c14-11(16)7-6-10(12(17)18)15-13(19)20-8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,19)(H,17,18)/t10-/m0/s1

InChIKey

JIMLDJNLXLMGLX-JTQLQIEISA-N

LogP

0.6314999999999991

Topological Polar Surface Area

118.72000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

353

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Glutamine, N2-carboxy-, N2-benzyl ester, L-
N2-Benzyloxycarbonyl-L-glutamine
N-Carbobenzoxy-L-glutamine
L-Glutamine, N-[(phenylmethoxy)carbonyl]-
HY-W009339
((Benzyloxy)carbonyl)-L-glutamine
2650-64-8
DTXSID50883880
Cbz-L-Gln-OH
AKOS010385670
AKOS015924213
Carbobenzyloxy-L-glutamine
Cbz-Gln-OH
Z-L-GLN-OH
AC-17139
N2-((Phenylmethoxy)carbonyl)-L-glutamine
N-ALPHA-BENZYLOXYCARBONYL-L-GLUTAMINE
(2S)-5-amino-5-oxo-2-(phenylmethoxycarbonylamino)pentanoic acid
3-Chloro-5-hydroxymethylphenylboronic acid pinacol ester
(2S)-2-{[(benzyloxy)carbonyl]amino}-4-carbamoylbutanoic acid
N-benzyloxycarbony-L-glutamine
J-300129
Glutamine, N-(benzyloxy)carbonyl-
(S)-5-AMINO-2-(BENZYLOXYCARBONYLAMINO)-5-OXOPENTANOIC ACID
AS-12742
AMY25317
Z-Gln-OH, 99%
CS-W010055
SCHEMBL716987
Z-L-Glutamine
NSC 186903

MDL Number

MFCD00008043

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8)?

N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8) is a white crystalline solid with a molecular weight of approximately 365.34 g/mol. It has a solubility of about 120 mg/mL in water and is not particularly reactive under normal conditions. This compound has good stability but can be sensitive to strong reducing agents.

How is N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8) typically synthesized?

N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8) is synthesized via a multi-step process, often starting with L-glutamine as the primary substrate. The key steps involve protection of the amine group with a benzyloxycarbonyl (CBZ) group using appropriate reagents, followed by deprotection under specific conditions to yield the final product. This synthesis typically requires the use of catalysts and involves careful control of reaction conditions to achieve optimal yields.

What industries use N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8)?

N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8) is primarily used in the pharmaceutical industry for the production of intermediates and final drug products. It may also have applications in the polymer industry for advanced materials synthesis, and in the sensor and semiconductor sectors for specialized chemical processes.

What precautions should be taken when handling N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8)?

When handling N~2~-[(Benzyloxy)carbonyl]-L-glutamine (CAS: 2650-64-8), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of a spill, it should be handled in a fume hood, and the proper emergency procedures should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.