2-Pyridinethiol

Basic Information

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CAS Number

2637-34-5

Molecular Formula

C5H5NS

Molecular Weight

111.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

127-130 °C

Boiling Point

184.9°C at 760 mmHg

Water Solubility

50 g/L (20 ºC)

Flash Point

125 ºC

Solubility

Slightly soluble in chloroform, methanol and dimethyl sulfoxide.

Refractive Index

1.5605 (estimate)

SMILES

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C1=CC(=S)NC=C1

InChI

InChI=1S/C5H5NS/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)

InChIKey

WHMDPDGBKYUEMW-UHFFFAOYSA-N

LogP

1.3703

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

135

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Incompatible with strong bases, strong oxidizing agents.

Sensitiveness

Air Sensitive

Synonyms & References

English

2-Pyridinethiol; 2-Pyridinethione; 2-Pyridyl mercaptan; 2-Pyridylthiol; 2-Sulfanylpyridine
Pyrid-2-thione
2-pyridinylthiol
73018-10-7
1H-pyridine-2-thione
AKOS003596823
CHEMBL1235541
Pridine-2-thiol
Pyridinethione
BCP21833
2-mercapto-pyridine
2-Mercaptopyridine, ReagentPlus(R), 99%
Epitope ID:120365
29468-20-0
F9995-0226
2-Thiopyridine
Pyridin-2(1H)-thione
DB03329
SY009099
WLN: T6NJ BSH
AKOS000120194
Thiopyridone-2
NSC41337
2-Mercaptopyridine
EINECS 249-657-7
PS-6210
NS00028094
C5H5NS
Q15274000
thioxopyridine
A818409

MDL Number

MFCD00006285

Customs Code

2933399090

FAQ

What is 2-Pyridinethiol (CAS: 2637-34-5)?

2-Pyridinethiol is a thiol compound with the chemical formula C5H6NS. It features a sulfur atom bonded to the 2-position of a pyridine ring, giving it strong nucleophilic properties. This compound is typically a colorless liquid with a pungent odor and is soluble in polar solvents. It is widely used in organic synthesis and as a building block for pharmaceutical and industrial applications.

What are the main uses of 2-Pyridinethiol (CAS: 2637-34-5)?

2-Pyridinethiol (CAS: 2637-34-5) is primarily used in pharmaceutical research for developing drugs targeting neurological disorders. It also serves as a ligand in coordination chemistry and a precursor for dyes, pesticides, and functional materials. Its applications extend to organic synthesis and as an intermediate in the production of various chemical compounds.

Is 2-Pyridinethiol (CAS: 2637-34-5) safe?

2-Pyridinethiol (CAS: 2637-34-5) requires careful handling due to its potential to cause skin and respiratory irritation. Safety standards recommend using appropriate PPE, such as gloves and goggles, and working in well-ventilated areas. It is classified as a hazardous substance, and disposal must follow local regulations to minimize environmental impact.

How should 2-Pyridinethiol (CAS: 2637-34-5) be stored?

2-Pyridinethiol (CAS: 2637-34-5) should be stored in a cool, dry place (below 25°C), away from light and incompatible materials. Keep in a sealed, airtight container made of glass or HDPE to prevent moisture absorption. Ensure storage areas are well-ventilated and follow guidelines to maintain stability and safety.