(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid

Basic Information

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CAS Number

2584-71-6

Molecular Formula

C5H9NO3

Molecular Weight

131.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

243 °C (dec.)

Boiling Point

242.42°C (rough estimate)

Water Solubility

5 g/100 mL

Flash Point

168.6 °C

Refractive Index

1.4300 (estimate)

Specific Rotation

58 º (c=2, water 24 ºC)

SMILES

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C1C(CNC1C(=O)O)O

InChI

InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m1/s1

InChIKey

PMMYEEVYMWASQN-QWWZWVQMSA-N

LogP

-1.2061999999999997

Topological Polar Surface Area

69.56 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

125

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

cis-4-Hydroxy-D-proline, Vetec(TM) reagent grade, 98%
MFCD00005252
NSC 524341
D-allo-Hydroxyproline
cis-4-hydroxy-pyrrolidine-2-carboxylic acid
CHEMBL1229563
FT-0601717
cis-4-hydroxy-(D)-proline
(2R,4R)-4-hydroxy pyrrolidine-2-carboxylic acid
(cis)-4-Hydroxy-D-proline
4-hydroxyproline
DTXSID20180494
CHEBI:16231
EINECS 219-963-5
D-cis-Hydroxyproline
cis-4-hydroxy-d-prolin
(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
cis-4-Hydroxy-D-proline
h-d-cis-hyp-oh
HY-W008129
D-PROLINE, 4-HYDROXY-, (4R)-
AS-12556
AKOS000279991
4-Hydroxy-D-alloproline
SCHEMBL85624
cis4-hydroxy-D-proline
(R)-allo-Hydroxyproline
PMMYEEVYMWASQN-QWWZWVQMSA-N
BDBM50357230
UYA
AKOS005258604

MDL Number

MFCD00005252

Customs Code

2933990090

FAQ

What regulatory guidelines apply to (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6)?

The (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) falls under the scope of various regulatory guidelines. Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), it may be classified as a skin irritant. In the European Union, it is regulated under REACH, requiring manufacturers and importers to register substances above 1 tonne per year. FDA and EPA requirements apply for its use in pharmaceuticals and chemicals, respectively, focusing on safety and environmental impact.

Are there alternatives to (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) in synthesis?

There are several alternatives to (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) in synthesis, including other amino acids like 4-hydroxy-2-aminocyclohexanoic acid or cyclic amino acids like 2-aminopyrrolidine-2-carboxylic acid. These alternatives can serve similar functional roles in some chemical reactions, offering different reactivity profiles and potentially lower toxicity.

What is the market or research trend for (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6)?

The market for (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) is driven by its use in pharmaceuticals and as a precursor in chemical synthesis. Research trends are focusing on its applications in drug discovery and as a chiral reagent. Recent studies are exploring its use in developing new therapeutic agents, particularly in the areas of pain management and neurological disorders.

How should waste containing (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) be handled?

Waste containing (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 2584-71-6) should be collected in appropriate containers and stored under conditions that prevent spills. For disposal, it is recommended to incinerate the waste or use a professional hazardous waste disposal service. Environmental precautions include ensuring no contamination of water sources and proper labeling of waste containers. Compliance with local environmental regulations is essential.