2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile;2-[4-[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-(4-piperidin-1-ylbut-2-enoyl)piperazin-2-yl]acetonitrile

Basic Information

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CAS Number

25817-87-2

Molecular Formula

HfN

Molecular Weight

17.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

3305°C

SMILES

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CN(C)CC=CC(=O)N1CCN(CC1CC#N)C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=CC(=CC5=CC=CC=C54)O)F)OC.COC1=NC2=C(C(=C(C=C2C(=N1)N3CCN(C(C3)CC#N)C(=O)C=CCN4CCCCC4)Cl)C5=CC(=CC6=CC=CC=C65)O)F

InChI

InChI=1S/Hf.N

InChIKey

AIRRSBIRSIPRGM-UHFFFAOYSA-N

LogP

0.16199999999999998

Topological Polar Surface Area

35.0 Å²

Hydrogen Bond Donor/Acceptor

3 / 1

Complexity

2100

Synonyms & References

English

25817-87-2
CID 167672218
2-[4-[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile;2-[4-[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-(4-piperidin-1-ylbut-2-enoyl)piperazin-2-yl]acetonitrile
Hafnium nitride
Hafnium nitride (HfN)
Hafnium mononitride
Ultrafine Hafnium Nitride Nanometer Hafnium Nitride HfN Powder

MDL Number

MFCD00016129

FAQ

What regulatory guidelines apply to 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2)?

The compound 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) is subject to various regulatory guidelines. It must comply with the Chemicals in the European Union (REACH) regulations, which require registration, evaluation, authorization, and restriction of chemical substances. In the United States, it must adhere to the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) regulations, which include safety data sheets (SDS) and proper labeling. Additionally, it should be handled in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for chemical hazards.

Are there alternatives to 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) in synthesis?

There are alternative reagents and synthetic pathways that can be used in place of 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) for synthesis. For instance, similar quinazolines with different substituents can be used. Additionally, alternative piperazine derivatives or different functional groups can be explored to achieve similar structural features. It is important to consider the availability, cost, and reactivity of these alternatives.

What is the market or research trend for 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2)?

The market and research trends for 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) are primarily driven by its potential applications in the pharmaceutical industry due to its unique chemical structure. Recent research trends include its use in drug discovery and development, particularly for treating inflammatory and neurodegenerative diseases. Market trends indicate an increasing demand for such specialized compounds, driven by ongoing clinical trials and patent expiration of older drugs.

How should waste containing 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) be handled?

Waste containing 2-[4-[6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-methoxyquinazolin-4-yl]-1-[4-(dimethylamino)but-2-enoyl]piperazin-2-yl]acetonitrile (CAS: 25817-87-2) should be managed according to the appropriate waste disposal regulations. Waste liquid should be collected in suitable containers, labeled with the chemical name and CAS number, and stored in a designated area. For solid waste, it should be encapsulated or neutralized if necessary, then disposed of through a hazardous waste management facility. Environmental protection precautions include ensuring no spillage and proper ventilation during handling. It is advisable to consult with environmental health and safety (EHS) professionals for specific disposal procedures.