4-Iodotetrahydro-2H-pyran

Basic Information

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CAS Number

25637-18-7

Molecular Formula

C5H9IO

Molecular Weight

212.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Liquid

Boiling Point

208.1°C at 760 mmHg

Flash Point

79.689℃

SMILES

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C1COCCC1I

InChI

InChI=1S/C5H9IO/c6-5-1-3-7-4-2-5/h5H,1-4H2

InChIKey

JTRNQTFTRDPITG-UHFFFAOYSA-N

LogP

1.6004

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-Iodopentahydropyran
GS-3890
FT-0648508
PB13042
4-Iodooxacyclohexane
4-iodo-tetrahydro-2H-pyran
2H-PYRAN, TETRAHYDRO-4-IODO-
4-iodotetrahydro-2H-pyran
BCP11458
A817935
4-Iodotetrahydro-2H-pyran, AldrichCPR
4-Iodo-tetrahydro-pyran
DTXSID20383726
4-IODOTETRAHYDROPYRAN
CS-W004278
AKOS005259354
TETRAHYDRO-4-IODO-2H-PYRAN
MFCD06797467
25637-18-7
SCHEMBL172959
4-iodo-tetrahydropyran
EN300-104914
JTRNQTFTRDPITG-UHFFFAOYSA-N
C5H9IO
AM20090312
SY004489
W-206966
4-iodooxane
4-Iodotetrahydro-2H-pyran
4-iodanyloxane
4-Jod-tetrahydro-pyran

MDL Number

MFCD06797467

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 4-Iodotetrahydro-2H-pyran (CAS: 25637-18-7)?

4-Iodotetrahydro-2H-pyran is a crystalline compound with a molecular weight of approximately 235.97 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol, ethanol, and acetone. It is moderately reactive, particularly under basic conditions. The compound can undergo ring-opening reactions with bases and can be further functionalized through nucleophilic substitution reactions.

How is 4-Iodotetrahydro-2H-pyran (CAS: 25637-18-7) typically synthesized?

4-Iodotetrahydro-2H-pyran is typically synthesized through the iodination of tetrahydro-2H-pyran using iodine in the presence of a catalytic amount of base such as potassium carbonate. The reaction is carried out in an organic solvent like acetonitrile. The yield and selectivity of the reaction can be improved by optimizing reaction conditions such as temperature and solvent choice.

What industries use 4-Iodotetrahydro-2H-pyran (CAS: 25637-18-7)?

4-Iodotetrahydro-2H-pyran finds applications in the pharmaceutical industry as a precursor for drug synthesis, particularly in the development of heterocyclic compounds. It is also used in the synthesis of polymers and as a reagent in organic chemistry for various functionalization reactions. Additionally, it has potential uses in the production of sensors and semiconductors.

What precautions should be taken when handling 4-Iodotetrahydro-2H-pyran (CAS: 25637-18-7)?

When handling 4-Iodotetrahydro-2H-pyran, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. It should be handled in a well-ventilated area or a fume hood. In case of spillage, it should be cleaned up using appropriate chemical spill kits and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.