How is 4-Iodotetrahydro-2H-pyran (CAS: 25637-18-7) typically synthesized?

4-Iodotetrahydro-2H-pyran is typically synthesized through the iodination of tetrahydro-2H-pyran using iodine in the presence of a catalytic amount of base such as potassium carbonate. The reaction is carried out in an organic solvent like acetonitrile. The yield and selectivity of the reaction can be improved by optimizing reaction conditions such as temperature and solvent choice.